Biology:MTMR3
 Generic protein structure example |
Myotubularin-related protein 3 is a protein that in humans is encoded by the MTMR3 gene.[1][2][3]
This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene.[3]
References
- ↑ "A gene mutated in X-linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeast". Nat Genet 13 (2): 175–82. Jul 1996. doi:10.1038/ng0696-175. PMID 8640223.
- ↑ "Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human". Hum Mol Genet 7 (11): 1703–12. Dec 1998. doi:10.1093/hmg/7.11.1703. PMID 9736772.
- ↑ 3.0 3.1 "Entrez Gene: MTMR3 myotubularin related protein 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8897.
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