Biology:SELS (gene)

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Selenoprotein S, also known as SELS, is a human gene.

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Interactions

SELS (gene) has been shown to interact with Valosin-containing protein.

Further reading

• "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics 23 (1): 42–50. 1995. doi:10.1006/geno.1994.1457. PMID 7829101. 
• Maruyama K; Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Bonaldo MF; Lennon G; Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–156. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–9548. 2000. doi:10.1073/pnas.160270997. PMID 10931946. Bibcode: 2000PNAS...97.9543H. 
• "Tanis: a link between type 2 diabetes and inflammation?". Diabetes 51 (6): 1859–1866. 2002. doi:10.2337/diabetes.51.6.1859. PMID 12031974. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Elevation in Tanis expression alters glucose metabolism and insulin sensitivity in H4IIE cells". Diabetes 52 (4): 929–934. 2003. doi:10.2337/diabetes.52.4.929. PMID 12663463. 
• "Characterization of mammalian selenoproteomes". Science 300 (5624): 1439–1443. 2003. doi:10.1126/science.1083516. PMID 12775843. Bibcode: 2003Sci...300.1439K. http://digitalcommons.unl.edu/cgi/viewcontent.cgi?article=1072&context=biochemgladyshev. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "Regulation of the selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress - SelS is a novel glucose-regulated protein". FEBS Lett. 563 (1–3): 185–190. 2004. doi:10.1016/S0014-5793(04)00296-0. PMID 15063746. 
• "Relationship between serum amyloid A level and Tanis/SelS mRNA expression in skeletal muscle and adipose tissue from healthy and type 2 diabetic subjects". Diabetes 53 (6): 1424–1428. 2004. doi:10.2337/diabetes.53.6.1424. PMID 15161744. 
• "A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol". Nature 429 (6994): 841–847. 2004. doi:10.1038/nature02656. PMID 15215856. Bibcode: 2004Natur.429..841Y. 
• "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• Lilley BN; Ploegh HL (2006). "Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane". Proc. Natl. Acad. Sci. U.S.A. 102 (40): 14296–14301. doi:10.1073/pnas.0505014102. PMID 16186509. 
• "Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane". Proc. Natl. Acad. Sci. U.S.A. 102 (40): 14132–14138. 2006. doi:10.1073/pnas.0505006102. PMID 16186510. 
• "Genetic variation in selenoprotein S influences inflammatory response". Nat. Genet. 37 (11): 1234–1241. 2006. doi:10.1038/ng1655. PMID 16227999. 
• "Activation of the selenoprotein SEPS1 gene expression by pro-inflammatory cytokines in HepG2 cells". Cytokine 33 (5): 246–251. 2006. doi:10.1016/j.cyto.2006.02.005. PMID 16574427. 
• "Secretion of the glucose-regulated selenoprotein SEPS1 from hepatoma cells". Biochem. Biophys. Res. Commun. 356 (3): 636–641. 2007. doi:10.1016/j.bbrc.2007.03.018. PMID 17374524. 
• "The role of the selenoprotein S (SELS) gene -105G>A promoter polymorphism in inflammatory bowel disease and regulation of SELS gene expression in intestinal inflammation". Tissue Antigens 70 (3): 238–246. 2007. doi:10.1111/j.1399-0039.2007.00888.x. PMID 17661913.