Biology:SCUBE1
From HandWiki
 Generic protein structure example |
Signal peptide, CUB domain and EGF like domain containing 1 is a protein that in humans is encoded by the SCUBE1 gene. [1]
Function
This gene encodes a cell surface glycoprotein that is a member of the SCUBE (signal peptide, CUB domain, EGF (epidermal growth factor)-like protein) family. Family members have an amino-terminal signal peptide, nine copies of EGF-like repeats and a CUB domain at the carboxyl terminus. This protein is expressed in platelets and endothelial cells and may play an important role in vascular biology.
References
Further reading
- "Identification of a novel family of cell-surface proteins expressed in human vascular endothelium". J. Biol. Chem. 277 (48): 46364–73. 2002. doi:10.1074/jbc.M207410200. PMID 12270931.
- "A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles". Genes Immun. 12 (1): 51–8. 2011. doi:10.1038/gene.2010.47. PMID 20962850.
- "Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) level in hemodialysis patients and parameters affecting that level". Clin. Biochem. 45 (16–17): 1444–9. 2012. doi:10.1016/j.clinbiochem.2012.07.103. PMID 22874483.
- "Reduction of pro-tumorigenic activity of human prostate cancer-associated fibroblasts using Dlk1 or SCUBE1". Dis. Models Mech. 6 (2): 530–6. 2013. doi:10.1242/dmm.010355. PMID 23136397.
- "Is SCUBE 1 a new biomarker for gastric cancer?". Cancer Biomark 11 (5): 191–5. 2012. doi:10.3233/CBM-2012-00285. PMID 23220851.
- "The diagnostic and prognostic significance of SCUBE1 levels in Crimean-Congo hemorrhagic fever". Int. J. Infect. Dis. 17 (11): e1042–5. 2013. doi:10.1016/j.ijid.2013.03.014. PMID 23632301.
- "Elevated Serum Levels of SCUBE1, a Marker for Coagulation, in Patients with Breast Cancer". Tohoku J. Exp. Med. 237 (2): 127–32. 2015. doi:10.1620/tjem.237.127. PMID 26438214.
- "Electrostatics and N-glycan-mediated membrane tethering of SCUBE1 is critical for promoting bone morphogenetic protein signalling". Biochem. J. 473 (5): 661–72. 2016. doi:10.1042/BJ20151041. PMID 26699903.
- "Role of signal peptide-Cub-Egf domain-containing protein-1 in serum as a predictive biomarker of outcome after severe traumatic brain injury". Clin. Chim. Acta 456: 63–6. 2016. doi:10.1016/j.cca.2016.02.021. PMID 26940951.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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