Biology:Galectin-2
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Galectin-2 is a protein that in humans is encoded by the LGALS2 gene.[1][2][3]
The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to Lymphotoxin alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction.[3]
References
- ↑ "Genomic sequence and organization of two members of a human lectin gene family". Biochemistry 30 (1): 82–9. Feb 1991. doi:10.1021/bi00215a013. PMID 1988031.
- ↑ "Human galectin-2: novel inducer of T cell apoptosis with distinct profile of caspase activation". J Immunol 173 (6): 3825–37. Sep 2004. doi:10.4049/jimmunol.173.6.3825. PMID 15356130.
- ↑ 3.0 3.1 "Entrez Gene: LGALS2 lectin, galactoside-binding, soluble, 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3957.
Further reading
- "Isolation and expression of a gene encoding L-14-II, a new human soluble lactose-binding lectin.". J. Biol. Chem. 267 (15): 10601–6. 1992. doi:10.1016/S0021-9258(19)50059-X. PMID 1375225.
- "Evidence that a human soluble beta-galactoside-binding lectin is encoded by a family of genes.". Proc. Natl. Acad. Sci. U.S.A. 83 (20): 7603–7. 1986. doi:10.1073/pnas.83.20.7603. PMID 3020551. Bibcode: 1986PNAS...83.7603G.
- "X-ray crystal structure of the human dimeric S-Lac lectin, L-14-II, in complex with lactose at 2.9-A resolution.". J. Biol. Chem. 268 (36): 27034–8. 1994. doi:10.2210/pdb1hlc/pdb. PMID 8262940.
- "Crystallization and preliminary X-ray diffraction analysis of the human dimeric S-Lac lectin (L-14-II).". J. Mol. Biol. 233 (3): 553–5. 1993. doi:10.1006/jmbi.1993.1533. PMID 8411163.
- "Two members of the S-lac lectin gene family, LGALS1 and LGALS2, reside in close proximity on human chromosome 22q12-q13.". Genomics 15 (2): 418–20. 1993. doi:10.1006/geno.1993.1078. PMID 8449510.
- "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. 1999. doi:10.1038/990031. PMID 10591208. Bibcode: 1999Natur.402..489D.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro.". Nature 429 (6987): 72–5. 2004. doi:10.1038/nature02502. PMID 15129282. Bibcode: 2004Natur.429...72O.
- "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. 2005. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Genotype of galectin 2 (LGALS2) is associated with insulin-glucose profile in the British Women's Heart and Health Study.". Diabetologia 49 (4): 673–7. 2006. doi:10.1007/s00125-006-0145-3. PMID 16468038.
- "Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells.". Blood 109 (1): 219–27. 2007. doi:10.1182/blood-2006-03-007153. PMID 16940423.
- "LGALS2 functional variant rs7291467 is not associated with susceptibility to myocardial infarction in Caucasians.". Atherosclerosis 194 (1): 112–5. 2007. doi:10.1016/j.atherosclerosis.2006.10.004. PMID 17098239.
- "Lack of association between LTA and LGALS2 polymorphisms and myocardial infarction in Japanese and Korean populations.". Tissue Antigens 69 (3): 265–9. 2007. doi:10.1111/j.1399-0039.2006.00798.x. PMID 17493152.
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