Biology:DYX1C1
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 Generic protein structure example |
Dyslexia susceptibility 1 candidate gene 1 protein is a protein that in humans is encoded by the DYX1C1 gene.[1][2] This protein contains 420-amino acids with 3 tetratricopeptide repeat (TPR) domains, thought to mediate protein–protein interactions.
Clinical significance
A mutation in the DYX1C1 gene has been associated with deficits in reading ability (dyslexia).[1][3]
References
- ↑ 1.0 1.1 "A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain". Proc Natl Acad Sci U S A 100 (20): 11553–8. Oct 2003. doi:10.1073/pnas.1833911100. PMID 12954984.
- ↑ "Entrez Gene: DYX1C1 dyslexia susceptibility 1 candidate 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=161582.
- ↑ "Dyslexia and DYX1C1: deficits in reading and spelling associated with a missense mutation". Mol. Psychiatry 15 (12): 1190–6. November 2009. doi:10.1038/mp.2009.120. PMID 19901951.
Further reading
- "Dyslexia and DYX1C1: deficits in reading and spelling associated with a missense mutation". Mol. Psychiatry 15 (12): 1190–6. November 2009. doi:10.1038/mp.2009.120. PMID 19901951.
- "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548.
- "Evaluation of candidate genes for DYX1 and DYX2 in families with dyslexia.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (4): 556–60. 2007. doi:10.1002/ajmg.b.30471. PMID 17450541.
- "No support for association between dyslexia susceptibility 1 candidate 1 and developmental dyslexia.". Mol. Psychiatry 10 (3): 237–8. 2005. doi:10.1038/sj.mp.4001596. PMID 15477871.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Association of short-term memory with a variant within DYX1C1 in developmental dyslexia.". Genes, Brain and Behavior 6 (7): 640–6. 2007. doi:10.1111/j.1601-183X.2006.00291.x. PMID 17309662.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Putative functional alleles of DYX1C1 are not associated with dyslexia susceptibility in a large sample of sibling pairs from the UK.". J. Med. Genet. 41 (11): 853–7. 2005. doi:10.1136/jmg.2004.018341. PMID 15520411.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Support for EKN1 as the susceptibility locus for dyslexia on 15q21.". Mol. Psychiatry 9 (12): 1111–21. 2005. doi:10.1038/sj.mp.4001543. PMID 15249932.
- "Family-based association study of DYX1C1 variants in autism.". Eur. J. Hum. Genet. 13 (1): 127–30. 2005. doi:10.1038/sj.ejhg.5201272. PMID 15470369.
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