Biology:Compensatory growth (organ)

From HandWiki
Revision as of 22:23, 30 June 2023 by SpringEdit (talk | contribs) (over-write)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Short description: Type of regenerative growth

File:Journal.pone.0049735.g001.TIF Compensatory growth is a type of regenerative growth that can take place in a number of human organs after the organs are either damaged, removed, or cease to function.[1] Additionally, increased functional demand can also stimulate this growth in tissues and organs.[2] The growth can be a result of increased cell size (compensatory hypertrophy) or an increase in cell division (compensatory hyperplasia) or both.[3] For instance, if one kidney is surgically removed, the cells of the other kidney divide at an increased rate.[1] Eventually, the remaining kidney can grow until its mass approaches the combined mass of two kidneys.[1] Along with the kidneys, compensatory growth has also been characterized in a number of other tissues and organs including:

  • the adrenal glands[4][5]
  • the heart[5][6]
  • muscles[5]
  • the liver[5][7]
  • the lungs[8]
  • the pancreas (beta cells and acinar cells)[7]
  • the mammary gland[5]
  • the spleen (where bone marrow and lymphatic tissue undergo compensatory hypertrophy and assumes the spleen function during spleen injury)[5]
  • the testicles[5]
  • the thyroid gland[5][9]
  • the turbinates

A large number of growth factors and hormones are involved with compensatory growth, but the exact mechanism is not fully understood and probably varies between different organs.[1] Nevertheless, angiogenic growth factors which control the growth of blood vessels are particularly important because blood flow significantly determines the maximum growth of an organ.[1]

Compensatory growth may also refer to the accelerated growth following a period of slowed growth, particularly as a result of nutrient deprivation.

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Widmaier, E. P.; Raff, H.; Strang, K. T. (2006). Vander's Human Physiology: The Mechanisms Of Body Function (10th ed.). Boston, Mass: McGraw-Hill Companies. pp. 383. ISBN 978-0-07-282741-5. https://archive.org/details/humanphysiologym00vand_711. 
  2. ↑ Goss, R. (1965). "Kinetics of Compensatory Growth". The Quarterly Review of Biology 40 (2): 123–146. doi:10.1086/404538. PMID 14338253. 
  3. ↑ "compensatory growth (biology) -- Britannica Online Encyclopedia". http://www.britannica.com/EBchecked/topic/129769/compensatory-growth. Retrieved 10 June 2011. 
  4. ↑ Swale Vincent (1912). Internal secretion and the ductless glands. Arnold. p. 150. https://archive.org/details/internalsecreti00vincgoog. Retrieved 10 June 2011. 
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 Francis Delafield; Theophil Mitchell Prudden (1907). A text-book of pathology with an introductory section on post-mortem examinations and the methods of preserving and examining diseased tissues. William Wood and Company. pp. 61–62. https://archive.org/details/textbookofpathole8dela. Retrieved 10 June 2011. 
  6. ↑ M. I. Gabriel Khan (5 December 2005). Encyclopedia of heart diseases. Academic Press. pp. 493–494. ISBN 978-0-12-406061-6. https://books.google.com/books?id=xco9aJ_Y9XIC&pg=PA493. Retrieved 10 June 2011. 
  7. ↑ 7.0 7.1 Anthony Atala (2008). Principles of regenerative medicine. Academic Press. pp. 101–102. ISBN 978-0-12-369410-2. https://books.google.com/books?id=BG5paiwd5hgC&pg=PA101. Retrieved 10 June 2011. 
  8. ↑ Rannels, D. (1989). "Role of physical forces in compensatory growth of the lung". The American Journal of Physiology 257 (4 Pt 1): L179–L189. doi:10.1152/ajplung.1989.257.4.L179. PMID 2679138. 
  9. ↑ Harold Clarence Ernst (1919). The Journal of medical research. p. 199. https://books.google.com/books?id=xfKfAAAAMAAJ&pg=PA199. Retrieved 10 June 2011. 



Retrieved from "https://handwiki.org/wiki/index.php?title=Biology:Compensatory_growth_(organ)&oldid=3154044"