Biology:Caldesmon
Caldesmon is a protein that in humans is encoded by the CALD1 gene.[1][2]
Caldesmon is a calmodulin binding protein. Like calponin, caldesmon tonically inhibits the ATPase activity of myosin in smooth muscle.
This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to
Immunochemistry
In diagnostic immunochemistry, caldesmon is a marker for smooth muscle differentiation.
References
- ↑ "Characterization of cDNA clones encoding a human fibroblast caldesmon isoform and analysis of caldesmon expression in normal and transformed cells". J Biol Chem 266 (25): 16917–24. Oct 1991. doi:10.1016/S0021-9258(18)55390-4. PMID 1885618.
- ↑ Jump up to: 2.0 2.1 "Entrez Gene: CALD1 caldesmon 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=800.
Further reading
- Huber PA (1998). "Caldesmon". Int. J. Biochem. Cell Biol. 29 (8–9): 1047–51. doi:10.1016/S1357-2725(97)00004-6. PMID 9415999.
- Gusev NB (2002). "Some properties of caldesmon and calponin and the participation of these proteins in regulation of smooth muscle contraction and cytoskeleton formation". Biochemistry Mosc. 66 (10): 1112–21. doi:10.1023/A:1012480829618. PMID 11736632.
- Wang CL (2002). "Caldesmon and smooth-muscle regulation". Cell Biochem. Biophys. 35 (3): 275–88. doi:10.1385/CBB:35:3:275. PMID 11894847.
- "Calcium-dependent regulation of caldesmon by an 11-kDa smooth muscle calcium-binding protein, caltropin". Biochemistry 31 (47): 11896–901. 1992. doi:10.1021/bi00162a031. PMID 1445920.
- Hayashi K; Yano H; Hashida T et al. (1993). "Genomic structure of the human caldesmon gene". Proc. Natl. Acad. Sci. U.S.A. 89 (24): 12122–6. doi:10.1073/pnas.89.24.12122. PMID 1465449.
- Humphrey MB; Herrera-Sosa H; Gonzalez G et al. (1992). "Cloning of cDNAs encoding human caldesmons". Gene 112 (2): 197–204. doi:10.1016/0378-1119(92)90376-Z. PMID 1555769.
- "Phosphorylation sequences in h-caldesmon from phorbol ester-stimulated canine aortas". FEBS Lett. 302 (3): 223–6. 1992. doi:10.1016/0014-5793(92)80446-N. PMID 1601129.
- "Interaction between caldesmon and tropomyosin in the presence and absence of smooth muscle actin". Biochemistry 27 (22): 8388–93. 1989. doi:10.1021/bi00422a014. PMID 3242591.
- "Purification and characterization of erythrocyte caldesmon. Hypothesis for an actin-linked regulation of a contractile activity in the red blood cell membrane". Eur. J. Biochem. 219 (1–2): 503–11. 1994. doi:10.1111/j.1432-1033.1994.tb19965.x. PMID 8307018.
- "Over-expression of smooth muscle caldesmon in mouse fibroblasts". Cell Motil. Cytoskeleton 32 (3): 233–43. 1996. doi:10.1002/cm.970320307. PMID 8581978.
- "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548.
- Graether SP; Heinonen TY; Raharjo WH et al. (1997). "Tryptophan residues in caldesmon are major determinants for calmodulin binding". Biochemistry 36 (2): 364–9. doi:10.1021/bi962008k. PMID 9003189.
- "Tyrosine phosphorylation of caldesmon is required for binding to the Shc.Grb2 complex". J. Biol. Chem. 274 (47): 33807–13. 1999. doi:10.1074/jbc.274.47.33807. PMID 10559276.
- Adam L; Vadlamudi R; Mandal M et al. (2000). "Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1". J. Biol. Chem. 275 (16): 12041–50. doi:10.1074/jbc.275.16.12041. PMID 10766836.
- "Prenatal origins of human intrapulmonary arteries: formation and smooth muscle maturation". Am. J. Respir. Cell Mol. Biol. 23 (2): 194–203. 2000. doi:10.1165/ajrcmb.23.2.3975. PMID 10919986.
- Nimmrich I; Erdmann S; Melchers U et al. (2000). "Seven genes that are differentially transcribed in colorectal tumor cell lines". Cancer Lett. 160 (1): 37–43. doi:10.1016/S0304-3835(00)00553-X. PMID 11098082.
- Hisaoka M; Wei-Qi S; Jian W et al. (2003). "Specific but variable expression of h-caldesmon in leiomyosarcomas: an immunohistochemical reassessment of a novel myogenic marker". Appl. Immunohistochem. Mol. Morphol. 9 (4): 302–8. doi:10.1097/00022744-200112000-00003. PMID 11759055.
- "Purification of a calmodulin-binding protein from chicken gizzard that interacts with F-actin". Proc. Natl. Acad. Sci. U.S.A. 78 (9): 5652–5. Sep 1981. doi:10.1073/pnas.78.9.5652. PMID 6946503. Bibcode: 1981PNAS...78.5652S.
External links
- Caldesmon at the US National Library of Medicine Medical Subject Headings (MeSH)
![]() | Original source: https://en.wikipedia.org/wiki/Caldesmon.
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