Biography:Gil McVean

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Short description: British statistical geneticist (born 1973)
Gil McVean

FRS FMedSci
Professor Gilean McVean FMedSci FRS (cropped).jpg
McVean in 2016
Born
Gilean Alistair Tristram McVean

February 1973 (age 51)
NationalityBritish
Alma mater
Awards
  • Francis Crick Medal & Lecture (2010)[1]
  • Weldon Memorial Prize (2012)
  • Fellow of the Royal Society (2016)
  • Fellow of the Academy of Medical Sciences (2016)
Scientific career
Institutions
ThesisAdaptation and conflict : the differences between the sexes in mammalian genome evolution (1998)
Doctoral advisorLaurence Hurst[2][3][4]
Other academic advisors
WebsiteProfessor Gil McVean - University of Oxford

Gilean Alistair Tristram McVean FRS FMedSci[5] (born February 1973)[6] is a professor of statistical genetics at the University of Oxford,[7] fellow of Linacre College, Oxford and co-founder and director of Genomics plc.[6][8] He also co-chaired the 1000 Genomes Project analysis group.[9][10]

Education

Gilean McVean speaking at the 2010 GEM meeting at the Wellcome Trust Sanger Institute, Hinxton

From 1991-94, he completed a Bachelor of Arts degree in Biological Sciences at the University of Oxford.[11] He completed his PhD in the Department of Genetics at the University of Cambridge supervised by Laurence Hurst[12][13] in 1998.[3][14]

Career and research

McVean completed postdoctoral research at the University of Edinburgh from 1997 to 2000, supervised by Brian and Deborah Charlesworth.[15][14]

From 2000-04, he was a Royal Society University Research Fellow in the Department of Statistics at Oxford, where he has also been a University lecturer in Mathematical Genetics since 2004. He was reappointed in 2009 until retirement age.[16] In October 2006, he was appointed professor of statistical genetics at the University of Oxford.[17]

McVean's research[18] focuses on population genetics, statistics[19] and evolutionary biology including the International HapMap Project,[20][21] recombination rates in the human genome[22] and the 1000 Genomes Project.[23][24]

McVean developed a statistical method to look at recombination rate which helped to identify PRDM9 as a hotspot positioning gene.[25] In 2014, with Peter Donnelly, McVean co-founded Genomics plc, a genomics analysis company, as a corporate spin-off of the University of Oxford.[6] In 2017, he was a founding director of the Big Data Institute at the University of Oxford.[26]

Honours and awards

In 2006 McVean was awarded a Philip Leverhulme Prize.[27][28]

In 2010, McVean was awarded the Francis Crick Medal and delivered that year's lecture entitled "Our genomes, our history".[29]

In 2012, he was awarded the Weldon Memorial Prize.[30]

In 2013, he presented a talk TEDxWarwick entitled A Thousand Genomes a Thousand Stories.[31]

In May 2014, McVean was elected as a member of the European Molecular Biology Organisation.[32]

McVean was elected Fellow of the Royal Society (FRS) in 2016[5] and a Fellow of the Academy of Medical Sciences (FMedSci).[33][34]

References

  1. ↑ "Francis Crick Medal and Lecture 2010 - Our genomes, our history". https://royalsociety.org/science-events-and-lectures/2010/genomes-history/. 
  2. ↑ Hurst, L.; McVean, G. (1996). "A difficult phase for introns-early. Molecular evolution". Current Biology 6 (5): 533–36. doi:10.1016/S0960-9822(02)00535-3. PMID 8805261. 
  3. ↑ 3.0 3.1 McVean, Gilean Alistair Tristram (1998). Adaptation and conflict: the differences between the sexes in mammalian genome evolution (PhD thesis). University of Cambridge. OCLC 894602716.
  4. ↑ "Students and post-docs past and present in the Hurst laboratory". University of Bath. Archived on 15 May 2015. Error: If you specify |archivedate=, you must also specify |archiveurl=. http://people.bath.ac.uk/bssldh/LaurenceDHurst/Lab_members.html. 
  5. ↑ 5.0 5.1 Anon (2016). "Gilean McVean". London: Royal Society. Archived from the original on 29 April 2016. https://web.archive.org/web/20160429121403/https://royalsociety.org/people/gilean-mcvean-12885. 
  6. ↑ 6.0 6.1 6.2 Anon (2016). "Gilean MCVEAN Profile". London: Companies House. Archived from the original on 12 August 2016. https://web.archive.org/web/20160812100701/https://beta.companieshouse.gov.uk/officers/Vk-hS4VIl5UrT2x7UrxKzWVL6Mo/appointments. 
  7. ↑ McVean Group at the University of Oxford
  8. ↑ "Prof. Gil McVean - GENOMICS plc". http://www.genomicsplc.com/team/prof-gil-mcvean. 
  9. ↑ "Oct 10: 1000 Genomes project - Wellcome Trust Centre for Human Genetics". http://www.well.ox.ac.uk/oct-10-1000-genomes-project. 
  10. ↑ Gil McVean publications from Europe PubMed Central
  11. ↑ Gil McVean's Entry at ORCID
  12. ↑ McVean, G.T.; Hurst, L.D. (1997). "Evidence for a selectively favourable reduction in the mutation rate of the X chromosome". Nature 386 (6623): 388–92. doi:10.1038/386388a0. PMID 9121553. Bibcode: 1997Natur.386..388M. 
  13. ↑ Hurst, L.D.; McVean, G.T. (1996). "...And scandalous symbionts". Nature 381 (6584): 650–51. doi:10.1038/381650a0. PMID 8649507. Bibcode: 1996Natur.381..650H. 
  14. ↑ 14.0 14.1 "Gilean McVean profile". http://www.stats.ox.ac.uk/people/academic_staff/gilean_mcvean. 
  15. ↑ Charlesworth, D.; Charlesworth, B.; McVean, G. (2001). "Genome sequences and evolutionary biology, a two-way interaction". Trends in Ecology & Evolution 16 (5): 235–42. doi:10.1016/S0169-5347(01)02126-7. PMID 11301152. 
  16. ↑ "Oxford University Gazette - Reappointments". 14 May 2009. http://www.ox.ac.uk/gazette/2008-9/weekly/140509/exam.htm. 
  17. ↑ "Oxford University Gazette". http://www.ox.ac.uk/gazette/2006-7/supps/1_4784.htm. 
  18. ↑ Gilean McVean profile, Google Scholar; accessed 30 December 2017.
  19. ↑ Reshef, D. N.; Reshef, Y. A.; Finucane, H. K.; Grossman, S. R.; McVean, G.; Turnbaugh, P. J.; Lander, E. S.; Mitzenmacher, M. et al. (2011). "Detecting Novel Associations in Large Data Sets". Science 334 (6062): 1518–1524. doi:10.1126/science.1205438. PMID 22174245. Bibcode: 2011Sci...334.1518R. 
  20. ↑ Frazer, K. A.; Frazer, D. G.; Ballinger, D. R.; Cox, D. A.; Hinds, L. L.; Stuve, R. A.; Gibbs, J. W.; Belmont, A. et al. (2007). "A second generation human haplotype map of over 3.1 million SNPs". Nature 449 (7164): 851–61. doi:10.1038/nature06258. PMID 17943122. Bibcode: 2007Natur.449..851F. 
  21. ↑ Sabeti, Pardis C.; Varilly, Patrick; Fry, Ben; Lohmueller, Jason; Hostetter, Elizabeth; Cotsapas, Chris; Xie, Xiaohui; Byrne, Elizabeth H. et al. (2007). "Genome-wide detection and characterization of positive selection in human populations". Nature 449 (7164): 913–918. doi:10.1038/nature06250. PMID 17943131. Bibcode: 2007Natur.449..913S. 
  22. ↑ McVean, G. A. T.; Myers, S.; Hunt, S.; Deloukas, P.; Bentley, D.; Donnelly, P. (2004). "The Fine-Scale Structure of Recombination Rate Variation in the Human Genome". Science 304 (5670): 581–584. doi:10.1126/science.1092500. PMID 15105499. Bibcode: 2004Sci...304..581M. 
  23. ↑ Danecek, P.; Auton, A.; Abecasis, G.; Albers, C. A.; Banks, E.; Depristo, M. A.; Handsaker, R.; Lunter, G. et al. (2011). "The Variant Call Format and VCFtools". Bioinformatics 27 (15): 2156–58. doi:10.1093/bioinformatics/btr330. PMID 21653522. 
  24. ↑ Hernandez, R. D.; Kelley, J. L.; Elyashiv, E.; Melton, S. C.; Auton, A.; McVean, G.; 1000 Genomes Project; Sella, G. et al. (2011). "Classic Selective Sweeps Were Rare in Recent Human Evolution". Science 331 (6019): 920–24. doi:10.1126/science.1198878. PMID 21330547. Bibcode: 2011Sci...331..920H. 
  25. ↑ "Gilean McVean". https://royalsociety.org/people/gilean-mcvean-12885/. 
  26. ↑ "Professor Cecilia Lindgren appointed Director of the Big Data Institute — Oxford Big Data Institute". https://www.bdi.ox.ac.uk/news/professor-cecilia-lindgren-appointed-director-of-the-big-data-institute. 
  27. ↑ "AWARDS MADE IN 2006". The Leverhulme Trust. 2006. https://www.leverhulme.ac.uk/sites/default/files/imported_pdfs/2006.pdf. 
  28. ↑ "Philip Leverhulme Prizes 2006". The Leverhulme Trust. 2006. https://www.leverhulme.ac.uk/sites/default/files/imported_pdfs/philip_prize_2006.pdf. 
  29. ↑ The Royal Society (10 December 2013), Our genomes, our history, https://www.youtube.com/watch?v=_noqZ2jm_74, retrieved 30 December 2017 
  30. ↑ "Professor Gil McVean awarded the Weldon Memorial Prize 2012 - Wellcome Trust Centre for Human Genetics". http://www.well.ox.ac.uk/professor-gil-mcvean-awarded-the-weldon-memorial-prize-2012. 
  31. ↑ TEDx Talks (2013-03-29), A Thousand Genomes a Thousand Stories: Gilean McVean at TEDxWarwick 2013, https://www.youtube.com/watch?v=LBn__zsd7-4, retrieved 30 December 2017 
  32. ↑ "EMBO enlarges its membership for 50th anniversary". http://www.embo.org/news/press-releases/2014/embo-enlarges-its-membership-for-50th-anniversary. 
  33. ↑ "New Fellows: Academy of Medical Sciences". http://www.acmedsci.ac.uk/fellows/fellowship-news/new-fellows. 
  34. ↑ "Professor Gil McVean elected a Fellow of the Royal Society - GENOMICS plc". http://www.genomicsplc.com/professor-gil-mcvean-elected-a-fellow-of-the-royal-society/. 



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