Chemistry:Olezarsen

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Olezarsen
Identifiers
CAS Number
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Olezarsen is a drug designed to block the production of apolipoprotein C-III and lower its concentrations to treat people with familial hypercholesterolemia and hypertriglyceridemia.[1][2][3]

References

  1. Spagnuolo, Catherine M; Hegele, Robert A (2023). "Recent advances in treating hypertriglyceridemia in patients at high risk of cardiovascular disease with apolipoprotein C-III inhibitors" (in en). Expert Opinion on Pharmacotherapy 24 (9): 1013–1020. doi:10.1080/14656566.2023.2206015. ISSN 1465-6566. 
  2. Karwatowska-Prokopczuk, Ewa; Tardif, Jean-Claude; Gaudet, Daniel; Ballantyne, Christie M.; Shapiro, Michael D.; Moriarty, Patrick M.; Baum, Seth J.; Amour, Eric St et al. (2022). "Effect of olezarsen targeting APOC-III on lipoprotein size and particle number measured by NMR in patients with hypertriglyceridemia". Journal of Clinical Lipidology 16 (5): 617–625. doi:10.1016/j.jacl.2022.06.005. ISSN 1933-2874. https://pubmed.ncbi.nlm.nih.gov/35902351/. 
  3. Tardif, Jean-Claude; Karwatowska-Prokopczuk, Ewa; Amour, Eric St; Ballantyne, Christie M; Shapiro, Michael D; Moriarty, Patrick M; Baum, Seth J; Hurh, Eunju et al. (6 April 2022). "Apolipoprotein C-III reduction in subjects with moderate hypertriglyceridaemia and at high cardiovascular risk". European Heart Journal 43 (14): 1401–1412. doi:10.1093/eurheartj/ehab820. https://academic.oup.com/eurheartj/article/43/14/1401/6506552.