Chemistry:Bohlmann–Rahtz pyridine synthesis
From HandWiki
| Bohlmann–Rahtz pyridine synthesis | |
|---|---|
| Named after | Ferdinand Bohlmann Dieter Rahtz |
| Reaction type | Ring forming reaction |
| Identifiers | |
| Organic Chemistry Portal | bohlmann-rahtz-pyridine-synthesis |
In organic chemistry, the Bohlmann–Rahtz pyridine synthesis is a reaction that generates substituted pyridines in two steps, first a condensation reaction between an enamine and an ethynylketone to form an aminodiene intermediate, which after heat-induced E/Z isomerization undergoes a cyclodehydration to yield 2,3,6-trisubstituted pyridines.[1][2][3][4]
References
- ↑ Bagley, Mark C.; Dale, James W.; Bower, Justin (January 2001). "A New Modification of the Bohlmann-Rahtz Pyridine Synthesis". Synlett 2001 (7): 1149–1151. doi:10.1055/s-2001-15140.
- ↑ Xiong, Xi; Bagley, Mark C.; Chapaneri, Krishna (2 August 2004). "A new mild method for the one-pot synthesis of pyridines". Tetrahedron Letters 45 (32): 6121–6124. doi:10.1016/j.tetlet.2004.06.061.
- ↑ Bagley, Mark C.; Fusillo, Vincenzo; Jenkins, Robert L.; Lubinu, M. Caterina; Mason, Christopher (2013). "One-step synthesis of pyridines and dihydropyridines in a continuous flow microwave reactor". Beilstein Journal of Organic Chemistry (Beilstein-Institut) 9 (1): 1957–1968. doi:10.3762/bjoc.9.232. PMID 24204407. PMC 3817555. https://doaj.org/article/e258ba00210547bfbb10713353f03b70.
- ↑ Dohe, Janis; Müller, Thomas J. J. (2016). "Consecutive three- and four-component coupling-Bagley-Bohlmann-Rahtz syntheses of tri- and tetrasubstituted pyridines.". Zeitschrift für Naturforschung B 71 (6): 705–718. doi:10.1515/znb-2016-0046.
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