Biography:Andrew Oates
Professor Andrew Oates | |
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![]() Andy Oates in 2020 | |
Born | 1969 (age 54–55) |
Citizenship | Australia n British |
Occupation | Full Professor |
Known for | Segmentation of the zebrafish body axis by the genetic oscillations |
Academic background | |
Education | Biology |
Alma mater | University of Adelaide University of Melbourne |
Doctoral advisor | Andrew F Wilks |
Other academic advisors | Robert Ho |
Academic work | |
Discipline | Biology |
Sub-discipline | Embryology |
Institutions | EPFL (École Polytechnique Fédérale de Lausanne) |
Main interests | Developmental biology Genetic oscillations Biophysics Embryology Synchronization |
Website | https://www.epfl.ch/labs/oateslab/ |
Andrew 'Andy' Charles Oates (born 1969 in Adelaide, Australia ) is an Australian and British developmental biologist and embryologist specialized in biological pattern formation. He is professor at EPFL (École Polytechnique Fédérale de Lausanne) and head of the Segmentation Timing and Dynamics Laboratory at EPFL's School of Life Sciences.[1][2][3] Since 2021, he has been dean of EPFL's School of Life Sciences.[4]
Career
Oates received an undergraduate degree in biochemistry with honors for his work at the Robert Saint's laboratory at the University of Adelaide in 1992. He then joined Andrew F. Wilks at the Ludwig Institute for Cancer Research and at the University of Melbourne as PhD student, and graduated in 1998.[5] His postdoctoral time was at the laboratory of Robert Ho both at Princeton University and at University of Chicago, where he began his studies on the segmentation clock in zebrafish.[6] In 2003, he moved to the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden to start his research group.[7][8] In 2012, he became professor of vertebrate developmental genetics at University College London and moved his group to the National Institute for Medical Research at Mill Hill in London.[9] In April 2015, he became a member of the Francis Crick Institute in London.[10]
In 2016, he joined EPFL as a full professor, where he is the founder and director of the Timing, Oscillation, Patterns Laboratory at EPFL's School of Life Sciences.[1][2][3]
Since 2018, he has served as director of the EPFL's Institute of Bioengineering,[11] and since January 2021 he has been the dean of the EPFL's School of Life Sciences.[4]
Research
Oates' research laboratory is composed of biologists, engineers, and physicists. It draws on molecular genetics, quantitative imaging, and theoretical analysis in order to investigate populations of coupled genetic oscillators in vertebrate embryos, termed as segmentation clocks.[12] These systems drive the rhythmic, sequential, and precise formation of embryonic body segments, exhibiting rich spatial and temporal phenomena spanning from molecular to tissue scales.[13][14]
The laboratory' contributions are the direct connection of genes to segmentation rhythm, and the discovery that the rhythm also involves physical, collective processes at multi-cellular and tissue scales.[15][16]
Distinctions
Oates is a member of the British Society of Developmental Biology.[17] He is the recipient of the R.K. Mortenson Prize for Biochemistry 1991.
Selected works
- Negrete, Jose; Oates, Andrew C. (2019). "Embryonic lateral inhibition as optical modes: An analytical framework for mesoscopic pattern formation". Physical Review E 99 (4): 042417. doi:10.1103/PhysRevE.99.042417. PMID 31108612. Bibcode: 2019PhRvE..99d2417N.
- Lleras Forero, Laura; Narayanan, Rachna; Huitema, Leonie FA; Vanbergen, Maaike; Apschner, Alexander; Peterson-Maduro, Josi; Logister, Ive; Valentin, Guillaume et al. (2018). "Segmentation of the zebrafish axial skeleton relies on notochord sheath cells and not on the segmentation clock". eLife 7. doi:10.7554/eLife.33843. PMID 29624170.
- Richter, Sandra; Schulze, Ulrike; Tomançak, Pavel; Oates, Andrew C. (2017). "Small molecule screen in embryonic zebrafish using modular variations to target segmentation". Nature Communications 8 (1): 1901. doi:10.1038/s41467-017-01469-5. PMID 29196645. Bibcode: 2017NatCo...8.1901R.
- Liao, Bo-Kai; Jörg, David J.; Oates, Andrew C. (2016). "Faster embryonic segmentation through elevated Delta-Notch signalling". Nature Communications 7: 11861. doi:10.1038/ncomms11861. PMID 27302627. Bibcode: 2016NatCo...711861L.
- Webb, Alexis B.; Lengyel, Iván M.; Jörg, David J.; Valentin, Guillaume; Jülicher, Frank; Morelli, Luis G.; Oates, Andrew C. (2016). "Persistence, period and precision of autonomous cellular oscillators from the zebrafish segmentation clock". eLife 5. doi:10.7554/eLife.08438. PMID 26880542.
- Soroldoni, D.; Jorg, D. J.; Morelli, L. G.; Richmond, D. L.; Schindelin, J.; Julicher, F.; Oates, A. C. (2014). "A Doppler effect in embryonic pattern formation". Science 345 (6193): 222–225. doi:10.1126/science.1253089. PMID 25013078. Bibcode: 2014Sci...345..222S.
- Bajard, L.; Morelli, L. G.; Ares, S.; Pecreaux, J.; Julicher, F.; Oates, A. C. (2014). "WNT-regulated dynamics of positional information in zebrafish somitogenesis". Development 141 (6): 1381–1391. doi:10.1242/dev.093435. PMID 24595291.
- Schröter, Christian; Ares, Saúl; Morelli, Luis G.; Isakova, Alina; Hens, Korneel; Soroldoni, Daniele; Gajewski, Martin; Jülicher, Frank et al. (2012). "Topology and Dynamics of the Zebrafish Segmentation Clock Core Circuit". PLOS Biology 10 (7): e1001364. doi:10.1371/journal.pbio.1001364. PMID 22911291.
References
- ↑ 1.0 1.1 "Brexit: closer cooperation with the UK cannot replace participation in Horizon 2020 | ETH-Board". https://www.ethrat.ch/en/medien-medienmitteilungen/brexit-engere-zusammenarbeit-mit-grossbritannien-kann-teilnahme-horizon-2020-nicht-ersetzen.
- ↑ 2.0 2.1 "oateslab" (in en-GB). https://www.epfl.ch/labs/oateslab/.
- ↑ 3.0 3.1 "Andrew Charles Oates". https://people.epfl.ch/andrew.oates/?lang=en.
- ↑ 4.0 4.1 (in en) New deans for the Basic Sciences and Life Sciences. 2020-11-12. https://actu.epfl.ch/news/new-deans-for-the-basic-sciences-and-life-sciences/.
- ↑ Nicholson, S. E.; Oates, A. C.; Harpur, A. G.; Ziemiecki, A.; Wilks, A. F.; Layton, J. E. (1994-04-12). "Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation." (in en). Proceedings of the National Academy of Sciences 91 (8): 2985–2988. doi:10.1073/pnas.91.8.2985. ISSN 0027-8424. PMID 7512720. Bibcode: 1994PNAS...91.2985N.
- ↑ Oates, Andrew C; Bruce, Ashley E.E; Ho, Robert K (August 2000). "Too Much Interference: Injection of Double-Stranded RNA Has Nonspecific Effects in the Zebrafish Embryo" (in en). Developmental Biology 224 (1): 20–28. doi:10.1006/dbio.2000.9761. PMID 10898958.
- ↑ Schröter, Christian; Herrgen, Leah; Cardona, Albert; Brouhard, Gary J.; Feldman, Benjamin; Oates, Andrew C. (March 2008). "Dynamics of zebrafish somitogenesis" (in en). Developmental Dynamics 237 (3): 545–553. doi:10.1002/dvdy.21458. PMID 18265021. http://doi.wiley.com/10.1002/dvdy.21458.
- ↑ Uriu, Koichiro; Ares, Saúl; Oates, Andrew C.; Morelli, Luis G. (2013-03-21). "Dynamics of mobile coupled phase oscillators" (in en). Physical Review E 87 (3): 032911. doi:10.1103/PhysRevE.87.032911. ISSN 1539-3755. Bibcode: 2013PhRvE..87c2911U. https://link.aps.org/doi/10.1103/PhysRevE.87.032911.
- ↑ Soroldoni, D.; Jorg, D. J.; Morelli, L. G.; Richmond, D. L.; Schindelin, J.; Julicher, F.; Oates, A. C. (2014-07-11). "A Doppler effect in embryonic pattern formation" (in en). Science 345 (6193): 222–225. doi:10.1126/science.1253089. ISSN 0036-8075. PMID 25013078. Bibcode: 2014Sci...345..222S.
- ↑ "King's College London - Randall Seminar: Professor Andrew Oates". https://www.kcl.ac.uk/lsm/newsevents/eventrecords/2015/may/randall-seminar-professor-andrew-oates.
- ↑ Sanctuary, Hillary (2020-08-25) (in en). Andrew Oates, a Passion for Cycles. https://actu.epfl.ch/news/andrew-oates-a-passion-for-cycles-2/.
- ↑ Naganathan, Sundar R.; Oates, Andrew C. (October 2017). "Mechanochemical coupling and developmental pattern formation" (in en). Current Opinion in Systems Biology 5: 104–111. doi:10.1016/j.coisb.2017.09.007. https://linkinghub.elsevier.com/retrieve/pii/S2452310017300999.
- ↑ "Research" (in en-GB). https://www.epfl.ch/labs/oateslab/page-141506-en-html/.
- ↑ Lleras Forero, Laura; Narayanan, Rachna; Huitema, Leonie FA; VanBergen, Maaike; Apschner, Alexander; Peterson-Maduro, Josi; Logister, Ive; Valentin, Guillaume et al. (2018-04-06). Whitfield, Tanya T.. ed. "Segmentation of the zebrafish axial skeleton relies on notochord sheath cells and not on the segmentation clock". eLife 7: e33843. doi:10.7554/eLife.33843. ISSN 2050-084X. PMID 29624170.
- ↑ Oates, Andrew C (August 2020). "Waiting on the Fringe: cell autonomy and signaling delays in segmentation clocks" (in en). Current Opinion in Genetics & Development 63: 61–70. doi:10.1016/j.gde.2020.04.008. PMID 32505051.
- ↑ Venzin, Olivier F.; Oates, Andrew C. (April 2020). "What are you synching about? Emerging complexity of Notch signaling in the segmentation clock" (in en). Developmental Biology 460 (1): 40–54. doi:10.1016/j.ydbio.2019.06.024. PMID 31302101.
- ↑ "Newsletter". http://bsdb.org/wp-content/uploads/BSDB-Newsletter-2015-12b.pdf.
External links
- Andrew Oates publications indexed by Google Scholar
- Website of the Segmentation Timing and Dynamics Laboratory