Biology:NKX3-3
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Short description: Gene
NK3 homeobox 3, also known as NKX3-3, zax, bagpipe homeobox or zampogna is a paralogous gene of NKX3-2. It is named after the italian instrument called zampogna.[1] NKX3-3 is not present in the human genome.[2]
Function
NKX3-3 is a homeodomain transcription factor. It plays a role in the development of the larval skeleton of anuran tadpoles. A knockdown of this NKX3-2 related homeobox gene in Xenopus laevis causes fatal head deformation, disappearing of jaw cartilages and shifted muscular insertions.[3]
References
- ↑ "The Xenopus bagpipe-related homeobox gene zampogna is expressed in the pharyngeal endoderm and the visceral musculature of the midgut". Development Genes and Evolution 209 (2): 132–4. February 1999. doi:10.1007/s004270050236. PMID 10022957.
- ↑ "Conservatism and variability of gene expression profiles among homeologous transcription factors in Xenopus laevis". Developmental Biology 426 (2): 301–24. June 2017. doi:10.1016/j.ydbio.2016.09.017. PMID 27810169.
- ↑ Lukas, Paul; Schmidt, Jennifer; Olsson, Lennart (2020). "Knockdown of zax in Xenopus laevis leads to craniofacial malformations and the absence of the intramandibular joint" (in en). Vertebrate Zoology 70 (1): 14. doi:10.26049/VZ70-1-2020-02.
Further reading
- "A gene expression map of the larvalXenopus laevishead reveals developmental changes underlying the evolution of new skeletal elements.". Developmental Biology 397 (2): 293–304. 2015. doi:10.1016/j.ydbio.2014.10.016. PMID 25446275.
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