Biology:ADAMTS14
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Short description: Protein-coding gene in the species Homo sapiens
ADAMTS14 encodes a member of the ADAMTS protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. Mature enzyme is generated by the proteolytically process of the encoded preproprotein. The enzyme cleaves the amino-propeptides of fibrillar collagens, enabling collagen fibril formation prior to assembly of collagen, which is a major extracellular matrix (ECM) protein.[1][2]
References
- ↑ "ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif 14 [Homo sapiens (human) - Gene - NCBI"]. https://www.ncbi.nlm.nih.gov/gene/140766.
This article incorporates text from this source, which is in the public domain.
- ↑ "ADAMTS14 Gene - GeneCards | ATS14 Protein | ATS14 Antibody". https://www.genecards.org/cgi-bin/carddisp.pl?gene=ADAMTS14.
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