Biology:SGSM2
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Small G protein signaling modulator 2 is a protein that in humans is encoded by the SGSM2 gene.[1][2]
Clinical relevance
In a recent genome-wide association study, this gene has been associated with fasting glucose traits, type 2 diabetes and obesity.[3]
References
- ↑ Yang, H (2007). "Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway.". Genomics 90 (2): 249–260. doi:10.1016/j.ygeno.2007.03.013. PMID 17509819.
- ↑ "Entrez Gene: small G protein signaling modulator 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9905.
- ↑ Strawbridge, RJ (2011-08-26). "Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes.". Diabetes 60 (10): 2624–34. doi:10.2337/db11-0415. PMID 21873549. PMC 3178302. https://archive-ouverte.unige.ch/unige:32202/ATTACHMENT01.
Further reading
- "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. 2005. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- "Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.". JAMA 302 (2): 168–78. 2009. doi:10.1001/jama.2009.978-a. PMID 19584346.
- "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 4 (5): 307–13. 1997. doi:10.1093/dnares/4.5.307. PMID 9455477.
- Yang H; Sasaki T; Minoshima S; Shimizu N (2007). "Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway.". Genomics 90 (2): 249–60. doi:10.1016/j.ygeno.2007.03.013. PMID 17509819.
- Ishibashi K; Kanno E; Itoh T; Fukuda M (2009). "Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity.". Genes Cells 14 (1): 41–52. doi:10.1111/j.1365-2443.2008.01251.x. PMID 19077034.
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