Biology:EIF4EBP3
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Eukaryotic translation initiation factor 4E-binding protein 3 is a protein that in humans is encoded by the EIF4EBP3 gene.[1][2]
Function
This gene encodes a member of the EIF4EBP family which derives its name from proteins that bind to eukaryotic initiation factor 4E and that prevent its assembly into EIF4F. Co-transcription of this gene and the neighboring upstream gene (MASK) generates a transcript (MASK-BP3) which encodes a fusion protein composed of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments.[2]
Interactions
EIF4EBP3 has been shown to interact with EIF4E.[1][3]
References
- ↑ 1.0 1.1 "4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family". J. Biol. Chem. 273 (22): 14002–7. Jul 1998. doi:10.1074/jbc.273.22.14002. PMID 9593750.
- ↑ 2.0 2.1 "Entrez Gene: EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8637.
- ↑ "Localisation and regulation of the eIF4E-binding protein 4E-BP3". FEBS Lett. 532 (3): 319–23. Dec 2002. doi:10.1016/S0014-5793(02)03694-3. PMID 12482586.
Further reading
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Characterization of mammalian eIF4E-family members". Eur. J. Biochem. 271 (11): 2189–203. 2004. doi:10.1111/j.1432-1033.2004.04149.x. PMID 15153109.
- "Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK". J. Biol. Chem. 278 (52): 52290–7. 2003. doi:10.1074/jbc.M310761200. PMID 14557257.
- "Ser-64 and Ser-111 in PHAS-I are dispensable for insulin-stimulated dissociation from eIF4E". J. Biol. Chem. 278 (48): 47459–65. 2003. doi:10.1074/jbc.M307949200. PMID 14507920.
- "Localisation and regulation of the eIF4E-binding protein 4E-BP3". FEBS Lett. 532 (3): 319–23. 2002. doi:10.1016/S0014-5793(02)03694-3. PMID 12482586.
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