Biology:WFIKKN2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 is a protein that in humans is encoded by the WFIKKN2 gene.

Function

The WFIKKN1 protein contains a WAP domain, follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AY358142.1, AK127743.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025083, ERS025084 [ECO:0000348] ##Evidence-Data-END##

See also

• Kazal-type serine protease inhibitor domain

Further reading

• "WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity". The FEBS Journal 277 (24): 5040–50. December 2010. doi:10.1111/j.1742-4658.2010.07909.x. PMID 21054789. 
• "Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains". Molecular Endocrinology 17 (6): 1144–54. June 2003. doi:10.1210/me.2002-0366. PMID 12595574. 
• "Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11". The Journal of Biological Chemistry 283 (35): 23677–84. August 2008. doi:10.1074/jbc.M803025200. PMID 18596030. 
• "Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein". European Journal of Biochemistry 270 (9): 2101–7. May 2003. doi:10.1046/j.1432-1033.2003.03593.x. PMID 12709070. 
• "Hormone therapy and maximal eccentric exercise alters myostatin-related gene expression in postmenopausal women". Journal of Strength and Conditioning Research 26 (5): 1374–82. May 2012. doi:10.1519/JSC.0b013e318251083f. PMID 22395277. 
• "Effects of oral creatine and resistance training on serum myostatin and GASP-1". Molecular and Cellular Endocrinology 317 (1–2): 25–30. April 2010. doi:10.1016/j.mce.2009.12.019. PMID 20026378. 
• "Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules". Biological Chemistry 383 (1): 223–8. January 2002. doi:10.1515/BC.2002.023. PMID 11928817. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.