Biology:NIMA-related kinase 1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
NIMA (never in mitosis gene a)-related kinase 1, also known as NEK1, is a human gene highly expressed in germ cells and thought to be involved in meiosis. It is also involved in the response to DNA damage from radiation; defects in this gene can be a cause of polycystic kidney disease.[1] NEK1 is thought to be involved in amytrophic lateral sclerosis.[2][3]
The gene was discovered by researchers with Project MinE, with the ALS Association providing funding raised through the Ice Bucket Challenge.[4]
See also
References
- ↑ "NEK1 NIMA related kinase 1 [Homo sapiens (human) - Gene - NCBI"]. https://www.ncbi.nlm.nih.gov/gene/4750.
- ↑ "Ice Bucket Challenge funds gene discovery in ALS (MND) research - BBC News" (in en-GB). BBC. 2016-07-27. https://www.bbc.com/news/health-36901867.
- ↑ "NEK1 variants confer susceptibility to amyotrophic lateral sclerosis". Nature Genetics 48 (9): 1037–42. July 2016. doi:10.1038/ng.3626. PMID 27455347.
- ↑ "ALS Ice Bucket Challenge Donations Lead to Significant Gene Discovery". July 25, 2016. http://www.alsa.org/news/media/press-releases/significant-gene-discovery-072516.html.
Further reading
- "A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells". The EMBO Journal 11 (10): 3521–31. October 1992. doi:10.1002/j.1460-2075.1992.tb05435.x. PMID 1382974.
- "Mutations in a NIMA-related kinase gene, Nek1, cause pleiotropic effects including a progressive polycystic kidney disease in mice". Proceedings of the National Academy of Sciences of the United States of America 97 (1): 217–21. January 2000. doi:10.1073/pnas.97.1.217. PMID 10618398. Bibcode: 2000PNAS...97..217U.
- "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth & Differentiation 4 (10): 821–30. October 1993. PMID 8274451.
- "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer 83 (4): 456–64. November 1999. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
- "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins". DNA Research 8 (4): 179–87. August 2001. doi:10.1093/dnares/8.4.179. PMID 11572484.
- "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1". Biochemistry 42 (51): 15369–76. December 2003. doi:10.1021/bi034575v. PMID 14690447.
- "A protein interaction framework for human mRNA degradation". Genome Research 14 (7): 1315–23. July 2004. doi:10.1101/gr.2122004. PMID 15231747.
- "Phosphoproteomic analysis of the developing mouse brain". Molecular & Cellular Proteomics 3 (11): 1093–101. November 2004. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
- "NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response". Cancer Research 64 (24): 8800–3. December 2004. doi:10.1158/0008-5472.CAN-04-2243. PMID 15604234.
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