Biology:ZC3H12A

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Zinc finger CCCH-type containing 12A is a protein in humans that is encoded by the ZC3H12A gene.[1]

ZC3H12A (also known as MCPIP-1 and Regnase-1) is an MCP1 (CCL2; MIM 158105)-induced protein that plays an important role in cell differentiation, apoptosis and the regulation of inflammation.

References

  1. ↑ "Entrez Gene: Zinc finger CCCH-type containing 12A". https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=80149. 

Further reading

  • "A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages". The Journal of Biological Chemistry 283 (10): 6337–46. 2008. doi:10.1074/jbc.M707861200. PMID 18178554. 
  • "Monocyte Chemotactic Protein-Induced Protein 1 (MCPIP-1): A Key Player of Host Defense and Immune Regulation.". Front Immunol. 12: 727861. 2021. doi:10.3389/fimmu.2021.727861. PMID 34659213. 




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