Biology:NCKAP1

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example


Nck-associated protein 1 is a protein that in humans is encoded by the NCKAP1 gene.[1][2][3][4]

Interactions

NCKAP1 has been shown to interact with RAC1[5] and ABI1.[6]

References

  1. "Molecular cloning of a novel apoptosis-related gene, human Nap1 (NCKAP1), and its possible relation to Alzheimer disease". Genomics 63 (2): 246–54. Jan 2000. doi:10.1006/geno.1999.6053. PMID 10673335. 
  2. "Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck". Nature 418 (6899): 790–3. Aug 2002. doi:10.1038/nature00859. PMID 12181570. Bibcode2002Natur.418..790E. 
  3. "A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs". Biochemical and Biophysical Research Communications 239 (2): 488–92. Oct 1997. doi:10.1006/bbrc.1997.7492. PMID 9344857. 
  4. "Entrez Gene: NCKAP1 NCK-associated protein 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10787. 
  5. "Interaction of Nck-associated protein 1 with activated GTP-binding protein Rac". The Biochemical Journal 322 (Pt 3): 873–8. Mar 1997. doi:10.1042/bj3220873. PMID 9148763. 
  6. "Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease". Gene 271 (2): 159–69. Jun 2001. doi:10.1016/S0378-1119(01)00521-2. PMID 11418237. 

Further reading