Biology:FSTL3

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Follistatin-related protein 3 is a protein that in humans is encoded by the FSTL3 gene.

Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis.

Further reading

• "FLRG, member of the follistatin family, a new player in hematopoiesis.". Mol. Cell. Endocrinol. 225 (1–2): 109–18. 2005. doi:10.1016/j.mce.2004.07.009. PMID 15451575. 
• "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. 2000. doi:10.1073/pnas.97.7.3491. PMID 10737800. Bibcode: 2000PNAS...97.3491D. 
• "Human follistatin-related protein: a structural homologue of follistatin with nuclear localization". Endocrinology 142 (8): 3426–34. 2001. doi:10.1210/endo.142.8.8319. PMID 11459787. 
• "FLRG, an activin-binding protein, is a new target of TGFbeta transcription activation through Smad proteins". Oncogene 20 (39): 5409–19. 2001. doi:10.1038/sj.onc.1204720. PMID 11571638. 
• "Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function". Oncogene 21 (14): 2227–35. 2002. doi:10.1038/sj.onc.1205294. PMID 11948405. 
• "The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum". J. Biol. Chem. 277 (43): 40735–41. 2002. doi:10.1074/jbc.M206379200. PMID 12194980. 
• "Regulation of follistatin-related gene (FLRG) expression by protein kinase C and prostaglandin E(2) in cultured granulosa-luteal cells". Mol. Hum. Reprod. 8 (11): 992–7. 2003. doi:10.1093/molehr/8.11.992. PMID 12397211. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Regulation of human erythropoiesis by activin A, BMP2, and BMP4, members of the TGFbeta family". Exp. Cell Res. 282 (2): 110–20. 2003. doi:10.1016/S0014-4827(02)00013-7. PMID 12531697. 
• "Follistatin-related gene (FLRG) expression in human endometrium: sex steroid hormones regulate the expression of FLRG in cultured human endometrial stromal cells". J. Clin. Endocrinol. Metab. 88 (9): 4432–9. 2003. doi:10.1210/jc.2002-021758. PMID 12970321. 
• "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. 2003. doi:10.1101/gr.1293003. PMID 12975309. 
• "Overexpression of follistatin-like 3 in gonads causes defects in gonadal development and function in transgenic mice". Mol. Endocrinol. 18 (4): 979–94. 2004. doi:10.1210/me.2003-0364. PMID 14739256. 
• "Human endometrium and decidua express follistatin-related gene (FLRG) mRNA and peptide". Mol. Cell. Endocrinol. 218 (1–2): 129–35. 2004. doi:10.1016/j.mce.2003.12.019. PMID 15130517. 
• "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. 2005. doi:10.1110/ps.04682504. PMID 15340161. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Differential biosynthesis and intracellular transport of follistatin isoforms and follistatin-like-3". Endocrinology 146 (12): 5052–62. 2006. doi:10.1210/en.2005-0833. PMID 16150905. 
• "IGFBP1 and Follistatin-like 3 genes are significantly up-regulated in expression profiles of the IUGR placenta". Placenta 27 (2–3): 317–21. 2006. doi:10.1016/j.placenta.2004.12.007. PMID 16338475. 

External links

• FSTL3 human gene location in the UCSC Genome Browser.
• FSTL3 human gene details in the UCSC Genome Browser.