Biology:NEGR1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Neuronal growth regulator 1 also known as NEGR1 is a protein which in humans is encoded by the NEGR1 gene.[1]
Clinical significance
Variants of the NEGR1 gene may be associated with obesity and major depression.[2][3][4]
References
- ↑ "Characterization of a novel rat brain glycosylphosphatidylinositol-anchored protein (Kilon), a member of the IgLON cell adhesion molecule family". J. Biol. Chem. 274 (12): 8224–30. March 1999. doi:10.1074/jbc.274.12.8224. PMID 10075727.
- ↑ "Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.". Nat. Genet. 41 (1): 18–24. January 2009. doi:10.1038/ng.274. PMID 19079260.
- ↑ "Six new loci associated with body mass index highlight a neuronal influence on body weight regulation". Nat. Genet. 41 (1): 24–34. January 2009. doi:10.1038/ng.287. PMID 19079261.
- ↑ "The role of obesity-associated loci identified in genome wide association studies in the determination of pediatric BMI". Obesity (Silver Spring) 17 (12): 2254–7. May 2009. doi:10.1038/oby.2009.159. PMID 19478790.
Further reading
- "Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment". J. Proteome Res. 5 (4): 935–43. 2006. doi:10.1021/pr050419u. PMID 16602701.
- "Novel Obesity Risk Loci Do Not Determine Distribution of Body Fat Depots: A Whole-body MRI/MRS study". Obesity (Silver Spring) 18 (6): 1212–7. 2009. doi:10.1038/oby.2009.413. PMID 19910938.
- "Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies". Am. J. Clin. Nutr. 91 (1): 184–90. 2010. doi:10.3945/ajcn.2009.28403. PMID 19812171.
- "Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?". Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (2): 695–9. 2010. doi:10.1002/ajmg.b.31026. PMID 19746409.
- "Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden". Hum. Mol. Genet. 18 (8): 1489–96. 2009. doi:10.1093/hmg/ddp041. PMID 19164386.
- "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. 2006. doi:10.1038/nature04727. PMID 16710414. Bibcode: 2006Natur.441..315G.
- "Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference". Am. J. Clin. Nutr. 90 (4): 951–9. 2009. doi:10.3945/ajcn.2009.27781. PMID 19692490.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX". N. Engl. J. Med. 358 (9): 900–9. 2008. doi:10.1056/NEJMoa0707865. PMID 18204098.
- "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. 2003. doi:10.1101/gr.1293003. PMID 12975309.
- "Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study". BMC Med. Genet. 8 (Suppl 1): S12. 2007. doi:10.1186/1471-2350-8-S1-S12. PMID 17903294.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population". J. Hum. Genet. 54 (12): 727–31. 2009. doi:10.1038/jhg.2009.106. PMID 19851340.
- "Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity". Nat. Genet. 41 (1): 18–24. 2009. doi:10.1038/ng.274. PMID 19079260.
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