Biology:SEPW1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Selenoprotein W is a protein that in humans is encoded by the SEPW1 gene.[1][2]
Function
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein shows highest expression in skeletal muscle and heart, and may be involved in oxidation-reduction reactions. A retroprocessed pseudogene, SEPW1P, has been identified and mapped to chromosome 1p35-34.[2]
References
- ↑ "Conserved features of selenocysteine insertion sequence (SECIS) elements in selenoprotein W cDNAs from five species". Gene 193 (2): 187–96. July 1997. doi:10.1016/S0378-1119(97)00113-3. PMID 9256076.
- ↑ 2.0 2.1 "Entrez Gene: SEPW1 selenoprotein W, 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6415.
Further reading
- "Selenoprotein W: a review". Cellular and Molecular Life Sciences 57 (13–14): 1846–52. December 2000. doi:10.1007/PL00000666. PMID 11215511.
- "Tissue distribution and influence of selenium status on levels of selenoprotein W". FASEB Journal 9 (5): 392–6. March 1995. doi:10.1096/fasebj.9.5.7896009. PMID 7896009.
- "A transcript map of the chromosome 19q-arm glioma tumor suppressor region". Genomics 64 (1): 44–50. February 2000. doi:10.1006/geno.1999.6101. PMID 10708517.
- "Characterization of mammalian selenoproteomes". Science 300 (5624): 1439–43. May 2003. doi:10.1126/science.1083516. PMID 12775843. Bibcode: 2003Sci...300.1439K. https://digitalcommons.unl.edu/biochemgladyshev/72.
- "Gene structure and tissue expression of human selenoprotein W, SEPW1, and identification of a retroprocessed pseudogene, SEPW1P". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1627 (2–3): 140–6. June 2003. doi:10.1016/s0167-4781(03)00078-2. PMID 12818432.
- "Effects of Se-depletion on glutathione peroxidase and selenoprotein W gene expression in the colon". FEBS Letters 579 (3): 792–6. January 2005. doi:10.1016/j.febslet.2004.12.042. PMID 15670848.
- "Selenoprotein W as molecular target of methylmercury in human neuronal cells is down-regulated by GSH depletion". Biochemical and Biophysical Research Communications 330 (4): 1095–102. May 2005. doi:10.1016/j.bbrc.2005.03.080. PMID 15823556.
External links
- Overview of all the structural information available in the PDB for UniProt: P63300 (Mouse Selenoprotein W) at the PDBe-KB.
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