Biology:Sauvagine
| Sauvagine | |||||||
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| Symbol | N/A | ||||||
| CAS number | 74434-59-6 | ||||||
| UniProt | P01144 | ||||||
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Sauvagine is a neuropeptide from the corticotropin-releasing factor (CRF) family of peptides and is orthologous to the mammalian hormone, urocortin 1, and the teleost fish hormone, urotensin 1.[1] It is 40 amino acids in length,[2] and has the sequence XGPPISIDLSLELLRKMIEIEKQEKEKQQAANNRLLLDTI-NH2, with a pyrrolidone carboxylic acid modification at the N-terminal and amidation of the C-terminal isoleucine residue. It was originally isolated from the skin of the frog Phyllomedusa sauvagii. Given its relation to other CRF-related peptides, it exerts similar physiological effects as corticotropin-releasing hormone.[3][4]
Sauvagine belongs to the corticotropin-releasing factor (CRF) family that also includes CRF, urocortin l/urotensin l, urocortin II and urocortin III.[5][1]
Interactions
Sauvagine has been shown to interact with corticotropin releasing factor receptors 1 and 2, and (as with other CRF-related peptides) is also bound by the corticotropin-releasing factor binding protein.[6]
References
- ↑ 1.0 1.1 "Evolution and phylogeny of the corticotropin-releasing factor (CRF) family of peptides: expansion and specialization in the vertebrates". Journal of Chemical Neuroanatomy 54: 50–6. December 2013. doi:10.1016/j.jchemneu.2013.09.006. PMID 24076419.
- ↑ "Amino acid composition and sequence analysis of sauvagine, a new active peptide from the skin of Phyllomedusa sauvagei". International Journal of Peptide and Protein Research 18 (2): 113–20. August 1981. doi:10.1111/j.1399-3011.1981.tb02047.x. PMID 7309372.
- ↑ "Potent in vivo and in vitro prolactin inhibiting activity of sauvagine, a frog skin peptide". Endocrinology 111 (2): 693–5. August 1982. doi:10.1210/endo-111-2-693. PMID 7094889.
- ↑ "Comparison of the biologic actions of corticotropin-releasing factor and sauvagine". Regulatory Peptides 4 (2): 107–14. July 1982. doi:10.1016/0167-0115(82)90101-X. PMID 6289384.
- ↑ "Physiology, pharmacology, and therapeutic relevance of urocortins in mammals: ancient CRF paralogs". Frontiers in Neuroendocrinology 28 (1): 1–27. April 2007. doi:10.1016/j.yfrne.2006.09.002. PMID 17083971.
- ↑ "Pharmacological characterization of recombinant rat corticotropin releasing factor binding protein using different sauvagine analogs". Peptides 22 (1): 47–56. January 2001. doi:10.1016/S0196-9781(00)00356-9. PMID 11179597.
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