Biology:TCF7L1
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Transcription factor 7-like 1, also known as TCF7L1, is a human gene.[1]
This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence.[1]
References
Further reading
- "A gene family of HMG-box transcription factors with homology to TCF-1". Nucleic Acids Research 20 (3): 611. Feb 1992. doi:10.1093/nar/20.3.611. PMID 1741298.
- "Mitomycin C resistance induced by TCF-3 overexpression in gastric cancer cell line MKN28 is associated with DT-diaphorase down-regulation". Cancer Research 60 (21): 5959–62. Nov 2000. PMID 11085512.
- "Identification of replicative senescence-associated genes in human umbilical vein endothelial cells by an annealing control primer system". Experimental Gerontology 43 (4): 286–95. Apr 2008. doi:10.1016/j.exger.2007.12.010. PMID 18258400. https://zenodo.org/record/895536.
- "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Molecular Medicine 16 (7–8): 247–53. 2010. doi:10.2119/molmed.2009.00159. PMID 20379614.
- "Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis". Stem Cell Reviews 3 (1): 30–8. Jan 2007. doi:10.1007/s12015-007-0006-6. PMID 17873379.
- "INTS6/DICE1 inhibits growth of human androgen-independent prostate cancer cells by altering the cell cycle profile and Wnt signaling". Cancer Cell International 9: 28. 2009. doi:10.1186/1475-2867-9-28. PMID 19906297.
- "TCF-3, 4 protein expression correlates with beta-catenin expression in MSS and MSI-H colorectal cancer from HNPCC patients but not in sporadic colorectal cancers". International Journal of Colorectal Disease 25 (8): 931–9. Aug 2010. doi:10.1007/s00384-010-0959-9. PMID 20532534.
- "Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling". Neuroscience Letters 412 (3): 211–6. Feb 2007. doi:10.1016/j.neulet.2006.07.045. PMID 17234346.
- "Candidate genes for sensitivity and resistance of human glioblastoma multiforme cell lines to erlotinib. Laboratory investigation". Journal of Neurosurgery 111 (2): 211–8. Aug 2009. doi:10.3171/2008.9.JNS08551. PMID 19301967.
- "Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium". The American Journal of Pathology 154 (1): 29–35. Jan 1999. doi:10.1016/S0002-9440(10)65247-9. PMID 9916915.
- "Wnt pathway genes in osteoporosis and osteoarthritis: differential expression and genetic association study". Osteoporosis International 21 (1): 109–18. Jan 2010. doi:10.1007/s00198-009-0931-0. PMID 19373426. http://uvadoc.uva.es/handle/10324/5947.
- "Crystal structure of a beta-catenin/Tcf complex". Cell 103 (6): 885–96. Dec 2000. doi:10.1016/S0092-8674(00)00192-6. PMID 11136974.
- "Dazap2 modulates transcription driven by the Wnt effector TCF-4". Nucleic Acids Research 37 (9): 3007–20. May 2009. doi:10.1093/nar/gkp179. PMID 19304756.
- "Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort". Molecular Psychiatry 14 (4): 351–3. Apr 2009. doi:10.1038/mp.2008.122. PMID 19308021.
- "Activation of the canonical wingless/T-cell factor signaling pathway promotes invasive differentiation of human trophoblast". The American Journal of Pathology 168 (4): 1134–47. Apr 2006. doi:10.2353/ajpath.2006.050686. PMID 16565489.
- "All Tcf HMG box transcription factors interact with Groucho-related co-repressors". Nucleic Acids Research 29 (7): 1410–9. Apr 2001. doi:10.1093/nar/29.7.1410. PMID 11266540.
 |  |
