Biology:NDRG2
From HandWiki
Short description: Protein-coding gene in humans
 Generic protein structure example |
Protein NDRG2 is a protein that in humans is encoded by the NDRG2 gene (NMYC downstream-regulated gene 2).[1][2]
Function
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma and aggressive meningioma carcinogenesis (via cell proliferation[3]).[4] Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[2]
References
- ↑ "N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom". Am J Hum Genet 67 (1): 47–58. Aug 2000. doi:10.1086/302978. PMID 10831399.
- ↑ 2.0 2.1 "Entrez Gene: NDRG2 NDRG family member 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57447.
- ↑ "N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation". Int. J. Cancer 106 (3): 342–7. September 2003. doi:10.1002/ijc.11228. PMID 12845671.
- ↑ "Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma". Cancer Res. 65 (16): 7121–6. August 2005. doi:10.1158/0008-5472.CAN-05-0043. PMID 16103061.
Further reading
- "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337–45. 2000. doi:10.1093/dnares/6.5.337. PMID 10574462.
- "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. 2001. doi:10.1101/gr.143000. PMID 11076863.
- "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. 2001. doi:10.1101/gr.GR1547R. PMID 11230166.
- "Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart.". Genomics 73 (1): 86–97. 2001. doi:10.1006/geno.2000.6496. PMID 11352569.
- "Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family.". Mol. Cell. Biochem. 229 (1–2): 35–44. 2002. doi:10.1023/A:1017934810825. PMID 11936845.
- "Inhibition of neurite outgrowth by reduced level of NDRG4 protein in antisense transfected PC12 cells.". Brain Res. Dev. Brain Res. 135 (1–2): 55–63. 2002. doi:10.1016/S0165-3806(02)00300-0. PMID 11978393.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation.". Int. J. Cancer 106 (3): 342–7. 2003. doi:10.1002/ijc.11228. PMID 12845671.
- "Expression and regulation of NDRG2 (N-myc downstream regulated gene 2) during the differentiation of dendritic cells.". FEBS Lett. 553 (3): 413–8. 2003. doi:10.1016/S0014-5793(03)01030-5. PMID 14572661.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases.". J. Biol. Chem. 279 (23): 24444–51. 2004. doi:10.1074/jbc.M401999200. PMID 15067004.
- "NDRG2: a novel Alzheimer's disease associated protein.". Neurobiol. Dis. 16 (1): 48–58. 2004. doi:10.1016/j.nbd.2004.01.003. PMID 15207261.
- "Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3.". Biochem. J. 384 (Pt 3): 477–88. 2005. doi:10.1042/BJ20041057. PMID 15461589.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. 2004. doi:10.1101/gr.2576704. PMID 15489336.
- "NDRG2 expression and mutation in human liver and pancreatic cancers.". World J. Gastroenterol. 10 (23): 3518–21. 2005. doi:10.3748/wjg.v10.i23.3518. PMID 15526377.
- "HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases.". Virology 331 (1): 181–9. 2005. doi:10.1016/j.virol.2004.10.023. PMID 15582665.
- "Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation.". FEBS Lett. 579 (3): 683–9. 2005. doi:10.1016/j.febslet.2004.12.045. PMID 15670829.
- "Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma.". Cancer Res. 65 (16): 7121–6. 2005. doi:10.1158/0008-5472.CAN-05-0043. PMID 16103061.
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