Biology:PTENP1
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Phosphatase and tensin homolog (mutated in multiple advanced cancers 1), pseudogene 1, also known as PTENP1, is a human pseudogene.[1] which has a partial reactivated function as a competing endogenous RNA regulating the tumor suppressor gene PTEN.[2]
References
- ↑ "Entrez Gene: PTENP1 phosphatase and tensin homolog (mutated in multiple advanced cancers 1), pseudogene 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11191.
- ↑ "A coding-independent function of gene and pseudogene mRNAs regulates tumour biology". Nature 465 (7301): 1033–8. June 2010. doi:10.1038/nature09144. PMID 20577206. Bibcode: 2010Natur.465.1033P.*Lay summary in: "The Complex Truth About ‘Junk DNA’". September 1, 2021. https://www.quantamagazine.org/the-complex-truth-about-junk-dna-20210901/.
Further reading
- "PTEN1 is frequently mutated in primary endometrial carcinomas". Nature Genetics 17 (2): 143–4. October 1997. doi:10.1038/ng1097-143. PMID 9326929.
- "MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines". Cancer Research 57 (23): 5221–5. December 1997. PMID 9393738.
- "Infrequent genetic alterations of the PTEN/MMAC1 gene in Japanese patients with primary cancers of the breast, lung, pancreas, kidney, and ovary". Japanese Journal of Cancer Research 88 (11): 1025–8. November 1997. doi:10.1111/j.1349-7006.1997.tb00324.x. PMID 9439675.
- "Alterations of PTEN/MMAC1, a candidate tumor suppressor gene, and its homologue, PTH2, in small cell lung cancer cell lines". Oncogene 16 (1): 89–93. January 1998. doi:10.1038/sj.onc.1201512. PMID 9467947.
- "A highly conserved processed PTEN pseudogene is located on chromosome band 9p21". Oncogene 16 (18): 2403–6. May 1998. doi:10.1038/sj.onc.1201762. PMID 9620558.
- "Mutation analysis of the PTEN/MMAC1 gene in lung cancer". Oncogene 17 (12): 1557–65. September 1998. doi:10.1038/sj.onc.1202070. PMID 9794233.
- "Transcriptional analysis of the PTEN/MMAC1 pseudogene, psiPTEN". Oncogene 18 (9): 1765–9. March 1999. doi:10.1038/sj.onc.1202492. PMID 10208437.
- "Activation of a cryptic splice site of PTEN and loss of heterozygosity in benign skin lesions in Cowden disease". The Journal of Investigative Dermatology 117 (6): 1650–3. December 2001. doi:10.1046/j.0022-202x.2001.01954.x. PMID 11886535.
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