Biology:MZF1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Myeloid zinc finger 1 is a protein that in humans is encoded by the MZF1 gene.[1][2]
Interactions
MZF1 has been shown to interact with SCAND1.[3] In 2014, the laboratory of Nathan H. Lents showed that MZF-1 induces the GAPDH gene, something that must be considered when GAPDH is used as a loading control in experiments that may induce or perturb MZF-1.[4] The same group later showed that MZF-1 induces CTGF and NOV, two members of the CCN gene family.[5]
References
- ↑ "A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells". J Biol Chem 266 (22): 14183–7. September 1991. doi:10.1016/S0021-9258(18)98664-3. PMID 1860835.
- ↑ "Entrez Gene: MZF1 myeloid zinc finger 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7593.
- ↑ "Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations". J. Biol. Chem. 275 (17): 12857–12867. April 2000. doi:10.1074/jbc.275.17.12857. PMID 10777584.
- ↑ "The glyceraldehyde 3-phosphate dehydrogenase gene (GAPDH) is regulated by myeloid zinc finger 1 (MZF-1) and is induced by calcitriol". Biochem. Biophys. Res. Commun. 451 (1): 137–41. 2014. doi:10.1016/j.bbrc.2014.07.082. PMID 25065746.
- ↑ "Myeloid Zinc Finger 1 (MZF-1) Regulates Expression of theCCN2/CTGFandCCN3/NOVGenes in the Hematopoietic Compartment". Journal of Cellular Physiology 230 (11): 2634–2639. 2015. doi:10.1002/jcp.25021. PMID 25899830.
Further reading
- "Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro". J. Exp. Med. 174 (5): 1097–1101. 1991. doi:10.1084/jem.174.5.1097. PMID 1719120.
- "Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations". J. Biol. Chem. 275 (17): 12857–12867. 2000. doi:10.1074/jbc.275.17.12857. PMID 10777584.
- "Human myeloid zinc finger gene MZF produces multiple transcripts and encodes a SCAN box protein". Gene 254 (1–2): 105–118. 2000. doi:10.1016/S0378-1119(00)00281-X. PMID 10974541.
- "FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF-1". Biochem. J. 386 (Pt 1): 191–200. 2005. doi:10.1042/BJ20040775. PMID 15453830.
- "Regulatory elements involved in transcription of the human NeuAcalpha2,3Galbeta1,3GalNAcalpha2,6-sialyltransferase (hST6GalNAc IV) gene". Mol. Cells 18 (2): 157–62. 2005. PMID 15528990.
- "Sp1/Sp3 and the myeloid zinc finger gene MZF1 regulate the human N-cadherin promoter in osteoblasts". Exp. Cell Res. 302 (1): 129–142. 2005. doi:10.1016/j.yexcr.2004.08.028. PMID 15541732.
- "LDOC1, a novel MZF-1-interacting protein, induces apoptosis". FEBS Lett. 579 (3): 604–608. 2005. doi:10.1016/j.febslet.2004.12.030. PMID 15670815.
- "PKCalpha expression regulated by Elk-1 and MZF-1 in human HCC cells". Biochem. Biophys. Res. Commun. 339 (1): 217–225. 2006. doi:10.1016/j.bbrc.2005.11.015. PMID 16297876.
- "Structure of the SCAN domain from the tumor suppressor protein MZF1". J. Mol. Biol. 363 (1): 137–147. 2006. doi:10.1016/j.jmb.2006.07.063. PMID 16950398.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–648. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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