Biology:EIF2C2
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Protein argonaute-2 is a protein that in humans is encoded by the EIF2C2 gene.[1][2][3]
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with Dicer1 and play a role in short-interfering-RNA-mediated gene silencing.[3]
Interactions
EIF2C2 has been shown to interact with
References
- ↑ "Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression". Genomics 61 (2): 210–8. Dec 1999. doi:10.1006/geno.1999.5951. PMID 10534406.
- ↑ "Identification of eight members of the Argonaute family in the human genome small star, filled". Genomics 82 (3): 323–30. Aug 2003. doi:10.1016/S0888-7543(03)00129-0. PMID 12906857.
- ↑ 3.0 3.1 "Entrez Gene: EIF2C2 eukaryotic translation initiation factor 2C, 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27161.
- ↑ "miRNP:mRNA association in polyribosomes in a human neuronal cell line". RNA 10 (3): 387–94. March 2004. doi:10.1261/rna.5181104. PMID 14970384.
- ↑ 5.0 5.1 "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6): 720–8. March 2002. doi:10.1101/gad.974702. PMID 11914277.
- ↑ "Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors". Curr. Biol. 13 (1): 41–6. January 2003. doi:10.1016/S0960-9822(02)01394-5. PMID 12526743.
- ↑ "Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway". Nat. Neurosci. 7 (2): 113–7. February 2004. doi:10.1038/nn1174. PMID 14703574.
- ↑ "A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain". Nat. Struct. Mol. Biol. 14 (10): 897–903. October 2007. doi:10.1038/nsmb1302. PMID 17891150.
Further reading
- "The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis.". Genes Dev. 16 (21): 2733–42. 2002. doi:10.1101/gad.1026102. PMID 12414724.
- "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs.". Genes Dev. 16 (6): 720–8. 2002. doi:10.1101/gad.974702. PMID 11914277.
- "Single-stranded antisense siRNAs guide target RNA cleavage in RNAi.". Cell 110 (5): 563–74. 2003. doi:10.1016/S0092-8674(02)00908-X. PMID 12230974.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors.". Curr. Biol. 13 (1): 41–6. 2003. doi:10.1016/S0960-9822(02)01394-5. PMID 12526743.
- "Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer.". EMBO Rep. 5 (2): 189–94. 2004. doi:10.1038/sj.embor.7400070. PMID 14749716.
- "miRNP:mRNA association in polyribosomes in a human neuronal cell line.". RNA 10 (3): 387–94. 2004. doi:10.1261/rna.5181104. PMID 14970384.
- "Argonaute2 is the catalytic engine of mammalian RNAi.". Science 305 (5689): 1437–41. 2004. doi:10.1126/science.1102513. PMID 15284456. Bibcode: 2004Sci...305.1437L.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Purified Argonaute2 and an siRNA form recombinant human RISC.". Nat. Struct. Mol. Biol. 12 (4): 340–9. 2005. doi:10.1038/nsmb918. PMID 15800637.
- "Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies.". Nat. Cell Biol. 7 (6): 633–6. 2005. doi:10.1038/ncb1265. PMID 15908945.
- "MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies.". Nat. Cell Biol. 7 (7): 719–23. 2005. doi:10.1038/ncb1274. PMID 15937477.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Small interfering RNAs containing full 2'-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity.". RNA 12 (1): 163–76. 2006. doi:10.1261/rna.2150806. PMID 16301602.
- "A human, ATP-independent, RISC assembly machine fueled by pre-miRNA.". Genes Dev. 19 (24): 2979–90. 2006. doi:10.1101/gad.1384005. PMID 16357216.
- "Functional replacement of Trypanosoma brucei Argonaute by the human slicer Argonaute2.". RNA 12 (6): 943–7. 2006. doi:10.1261/rna.20806. PMID 16611939.
- "Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies.". PLOS Pathog. 2 (5): e41. 2006. doi:10.1371/journal.ppat.0020041. PMID 16699599.
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