Biology:MicroRNA 93

Short description: Non-coding RNA in the species Homo sapiens

Generic protein structure example

MicroRNA 93 is a functional RNA and a microRNA that in humans is encoded by the MIR93 gene.

Function

The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70 nucleotide long stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target messenger RNAs (mRNA) through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Further reading

• "E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer". Cancer Cell 13 (3): 272–86. March 2008. doi:10.1016/j.ccr.2008.02.013. PMID 18328430. 
• "Roles for microRNAs, miR-93 and miR-130b, and tumor protein 53-induced nuclear protein 1 tumor suppressor in cell growth dysregulation by human T-cell lymphotrophic virus 1". Cancer Res. 68 (21): 8976–85. November 2008. doi:10.1158/0008-5472.CAN-08-0769. PMID 18974142. 
• "Role of the miR-106b-25 microRNA cluster in hepatocellular carcinoma". Cancer Sci. 100 (7): 1234–42. July 2009. doi:10.1111/j.1349-7006.2009.01164.x. PMID 19486339. 
• "miR-93, miR-98, and miR-197 regulate expression of tumor suppressor gene FUS1". Mol. Cancer Res. 7 (8): 1234–43. August 2009. doi:10.1158/1541-7786.MCR-08-0507. PMID 19671678. 
• "Novel genetic variants in miR-191 gene and familial ovarian cancer". BMC Cancer 10: 47. February 2010. doi:10.1186/1471-2407-10-47. PMID 20167074. 
• "microRNA-dependent modulation of histone acetylation in Waldenstrom macroglobulinemia". Blood 116 (9): 1506–14. September 2010. doi:10.1182/blood-2010-01-265686. PMID 20519629. 
• "Genetic polymorphisms in the precursor MicroRNA flanking region and non-small cell lung cancer survival". Am. J. Respir. Crit. Care Med. 183 (5): 641–8. March 2011. doi:10.1164/rccm.201005-0717OC. PMID 20889907. 
• "MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-β8". Oncogene 30 (7): 806–21. February 2011. doi:10.1038/onc.2010.465. PMID 20956944. 
• "Loss of p21(Sdi1) expression in senescent cells after DNA damage accompanied with increase of miR-93 expression and reduced p53 interaction with p21(Sdi1) gene promoter". Biochem. Biophys. Res. Commun. 407 (2): 406–11. April 2011. doi:10.1016/j.bbrc.2011.03.038. PMID 21402054. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.