Biology:DEK (gene)
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
The human DEK gene encodes the DEK protein.[1][2]
Function
This gene encodes a protein with one SAP domain. The protein binds to cruciform DNA and DNA coiled into a superhelix, thereby inducing positive supercoils into closed circular DNA. It is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region increased expression of this gene and the presence of antibodies against this protein are all associated with various diseases.[2]
Interactions
References
- ↑ "The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA". Mol. Cell. Biol. 12 (4): 1687–97. Apr 1992. doi:10.1128/mcb.12.4.1687. PMID 1549122.
- ↑ 2.0 2.1 "Entrez Gene: DEK DEK oncogene (DNA binding)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7913.
- ↑ "Transcriptional activation by AP-2alpha is modulated by the oncogene DEK". Nucleic Acids Res. 31 (5): 1571–5. Mar 2003. doi:10.1093/nar/gkg247. PMID 12595566.
Further reading
- "Translocation t(6;9) in acute non-lymphocytic leukaemia results in the formation of a DEK-CAN fusion gene". Baillière's Clinical Haematology 5 (4): 857–79. 1992. doi:10.1016/s0950-3536(11)80049-1. PMID 1308167.
- "The DEK protein--an abundant and ubiquitous constituent of mammalian chromatin". Gene 343 (1): 1–9. 2004. doi:10.1016/j.gene.2004.08.029. PMID 15563827.
- "Zik1, a transcriptional repressor that interacts with the heterogeneous nuclear ribonucleoprotein particle K protein". J. Biol. Chem. 271 (44): 27701–6. 1996. doi:10.1074/jbc.271.44.27701. PMID 8910362.
- "DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer". Proc. Natl. Acad. Sci. U.S.A. 94 (5): 1811–5. 1997. doi:10.1073/pnas.94.5.1811. PMID 9050861. Bibcode: 1997PNAS...94.1811F.
- "Antibodies to the 45 kDa DEK nuclear antigen in pauciarticular onset juvenile rheumatoid arthritis and iridocyclitis: selective association with MHC gene". J. Rheumatol. 24 (3): 560–7. 1997. PMID 9058666.
- "Juvenile arthritis, HLA-A2 and binding of DEK oncogene-peptides". Hum. Immunol. 59 (7): 443–50. 1998. doi:10.1016/S0198-8859(98)00034-2. PMID 9684994.
- "Autoantibodies to DEK oncoprotein in a patient with systemic lupus erythematosus and sarcoidosis". Arthritis Rheum. 41 (8): 1505–10. 1998. doi:10.1002/1529-0131(199808)41:8<1505::AID-ART23>3.0.CO;2-N. PMID 9704652.
- "Autoantibodies to transcriptional regulation proteins DEK and ALY in a patient with systemic lupus erythematosus". Hum. Immunol. 60 (1): 57–62. 1999. doi:10.1016/S0198-8859(98)00085-8. PMID 9952027.
- "The protein encoded by the proto-oncogene DEK changes the topology of chromatin and reduces the efficiency of DNA replication in a chromatin-specific manner". Genes Dev. 14 (11): 1308–12. 2000. doi:10.1101/gad.14.11.1308. PMID 10837023.
- "The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes". J. Cell Biol. 150 (2): 309–20. 2000. doi:10.1083/jcb.150.2.309. PMID 10908574.
- "Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs". Int. J. Cancer 88 (4): 535–46. 2000. doi:10.1002/1097-0215(20001115)88:4<535::AID-IJC4>3.0.CO;2-V. PMID 11058868.
- "The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions". EMBO J. 19 (24): 6860–9. 2000. doi:10.1093/emboj/19.24.6860. PMID 11118221.
- "Subcellular localization of the human proto-oncogene protein DEK". J. Biol. Chem. 276 (28): 26317–23. 2001. doi:10.1074/jbc.M100162200. PMID 11333257.
- "The ubiquitous chromatin protein DEK alters the structure of DNA by introducing positive supercoils". J. Biol. Chem. 277 (28): 24988–94. 2002. doi:10.1074/jbc.M204045200. PMID 11997399.
- "Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis". Haematologica 87 (6): 569–77. 2002. PMID 12031912.
- "Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek". J. Cell Sci. 115 (Pt 16): 3319–30. 2002. doi:10.1242/jcs.115.16.3319. PMID 12140263.
- "Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomes". J. Virol. 76 (22): 11596–604. 2002. doi:10.1128/JVI.76.22.11596-11604.2002. PMID 12388720.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein DEK
PDB gallery | |
|---|---|
|
 |  |
