Biology:RRAGB
 Generic protein structure example |
Ras-related GTP-binding protein B is a protein that in humans is encoded by the RRAGB gene.[1][2][3]
Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. MTORC1 responds to amino acids via interaction with RAGB.[3]
References
- ↑ "Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases". J Biol Chem 270 (48): 28982–8. Jan 1996. doi:10.1074/jbc.270.48.28982. PMID 7499430.
- ↑ "RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway". J Cell Sci. 111 ( Pt 1): 11–21. Feb 1998. doi:10.1242/jcs.111.1.11. PMID 9394008.
- ↑ 3.0 3.1 "Entrez Gene: RRAGB Ras-related GTP binding B". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10325.
Further reading
- "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. 2005. doi:10.1038/nature03440. PMID 15772651. Bibcode: 2005Natur.434..325R.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis.". Invest. Ophthalmol. Vis. Sci. 44 (6): 2588–96. 2003. doi:10.1167/iovs.02-1099. PMID 12766061.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B.". J. Biol. Chem. 276 (10): 7246–57. 2001. doi:10.1074/jbc.M004389200. PMID 11073942.
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