Biology:GZMM
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Granzyme M is a protein that in humans is encoded by the GZMM gene.[1][2]
Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and Met-ase, also known as granzyme M.[2]
References
- ↑ "The gene encoding a human natural killer cell granule serine protease, Met-ase 1, maps to chromosome 19p13.3". Immunogenetics 39 (4): 294–5. Apr 1994. doi:10.1007/bf00188796. PMID 8119738.
- ↑ 2.0 2.1 "Entrez Gene: GZMM granzyme M (lymphocyte met-ase 1)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3004.
Further reading
- "Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies.". J. Leukoc. Biol. 60 (5): 555–62. 1996. doi:10.1002/jlb.60.5.555. PMID 8929545.
- "The human Met-ase gene (GZMM): structure, sequence, and close physical linkage to the serine protease gene cluster on 19p13.3.". Genomics 24 (3): 445–50. 1995. doi:10.1006/geno.1994.1651. PMID 7713495.
- "Met-ase: cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells.". J. Immunol. 151 (11): 6195–205. 1994. PMID 8245461.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The serine protease granzyme M is preferentially expressed in NK-cell, gamma delta T-cell, and intestinal T-cell lymphomas: evidence of origin from lymphocytes involved in innate immunity.". Blood 101 (9): 3590–3. 2003. doi:10.1182/blood-2002-09-2908. PMID 12506019.
- "Granzyme M mediates a novel form of perforin-dependent cell death.". J. Biol. Chem. 279 (21): 22236–42. 2004. doi:10.1074/jbc.M401670200. PMID 15028722.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B.". J. Biol. Chem. 279 (52): 54275–82. 2005. doi:10.1074/jbc.M411482200. PMID 15494398.
- "Granzyme M directly cleaves inhibitor of caspase-activated DNase (CAD) to unleash CAD leading to DNA fragmentation.". J. Immunol. 177 (2): 1171–8. 2006. doi:10.4049/jimmunol.177.2.1171. PMID 16818775.
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