Biology:SPRY4
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Protein sprouty homolog 4 is a protein that in humans is encoded by the SPRY4 gene.[1][2]
Function
SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002).[2]
Interactions
SPRY4 has been shown to interact with TESK1.[3]
See also
- MAPK signaling pathway
- Ras subfamily
References
- ↑ "FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells". International Journal of Molecular Medicine 17 (3): 529–32. Mar 2006. doi:10.3892/ijmm.17.3.529. PMID 16465403.
- ↑ 2.0 2.1 "Entrez Gene: SPRY4 sprouty homolog 4 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81848.
- ↑ "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". European Journal of Biochemistry 269 (10): 2546–56. May 2002. doi:10.1046/j.1432-1033.2002.02921.x. PMID 12027893.
Further reading
- "Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping". BMC Psychiatry 8: 11. 2008. doi:10.1186/1471-244X-8-11. PMID 18298822.
- "A functional interaction between sprouty proteins and caveolin-1". The Journal of Biological Chemistry 281 (39): 29201–12. Sep 2006. doi:10.1074/jbc.M603921200. PMID 16877379.
- "Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer". The Prostate 66 (6): 613–24. May 2006. doi:10.1002/pros.20353. PMID 16388505.
- "Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis". American Journal of Physiology. Lung Cellular and Molecular Physiology 287 (1): L52-9. Jul 2004. doi:10.1152/ajplung.00430.2003. PMID 14977631.
- "Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1". Nature Cell Biology 5 (5): 427–32. May 2003. doi:10.1038/ncb978. PMID 12717443.
- "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". European Journal of Biochemistry 269 (10): 2546–56. May 2002. doi:10.1046/j.1432-1033.2002.02921.x. PMID 12027893.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein sprouty homolog 4 (SPRY4)
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