Biology:NAB2
 Generic protein structure example |
NGFI-A-binding protein 2 also known as EGR-1-binding protein 2 or melanoma-associated delayed early response protein (MADER) is a protein that in humans is encoded by the NAB2 gene.[1][2][3]
Function
This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress or activate transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[3]
Pathology
Recurrent somatic fusions of the two genes, NGFI-A–binding protein 2 (NAB2) and STAT6, located at chromosomal region 12q13, have been identified in solitary fibrous tumors.[4]
References
- ↑ "NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli". Mol Cell Biol 16 (7): 3545–53. Aug 1996. doi:10.1128/MCB.16.7.3545. PMID 8668170.
- ↑ "Mader: a novel nuclear protein over expressed in human melanomas". Oncogene 12 (5): 963–71. Jul 1996. PMID 8649813.
- ↑ 3.0 3.1 "Entrez Gene: NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4665.
- ↑ Kabbinavar, F. F.; Hambleton, J; Mass, R. D.; Hurwitz, H. I.; Bergsland, E; Sarkar, S (2005). "Combined analysis of efficacy: The addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer". Journal of Clinical Oncology 23 (16): 3706–12. doi:10.1200/JCO.2005.00.232. PMID 15867200.
Further reading
- "The Nab2 and Stat6 genes share a common transcription termination region.". Genomics 41 (1): 33–9. 1997. doi:10.1006/geno.1997.4609. PMID 9126479.
- "The transcriptional corepressor NAB2 inhibits NGF-induced differentiation of PC12 cells.". J. Cell Biol. 142 (4): 1075–82. 1998. doi:10.1083/jcb.142.4.1075. PMID 9722618.
- "Novel mutants of NAB corepressors enhance activation by Egr transactivators.". EMBO J. 17 (20): 6010–9. 1998. doi:10.1093/emboj/17.20.6010. PMID 9774344.
- "Impaired prostate tumorigenesis in Egr1-deficient mice.". Nat. Med. 7 (1): 101–7. 2001. doi:10.1038/83231. PMID 11135623.
- "Frequent and early loss of the EGR1 corepressor NAB2 in human prostate carcinoma.". Hum. Pathol. 32 (9): 935–9. 2001. doi:10.1053/hupa.2001.27102. PMID 11567222.
- "Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies.". Neurogenetics 4 (1): 37–41. 2003. doi:10.1007/s10048-001-0124-2. PMID 12030330.
- "NAB2, a corepressor of EGR-1, inhibits vascular endothelial growth factor-mediated gene induction and angiogenic responses of endothelial cells.". J. Biol. Chem. 278 (13): 11433–40. 2003. doi:10.1074/jbc.M204937200. PMID 12427750.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter thereby establishing a negative feedback loop.". J. Biol. Chem. 280 (52): 42785–93. 2005. doi:10.1074/jbc.M511079200. PMID 16260776.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex.". J. Biol. Chem. 281 (22): 15129–37. 2006. doi:10.1074/jbc.M600775200. PMID 16574654.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
 |  |
