Biology:Hepatitis C alternative reading frame stem-loop
| Hepatitis C alternative reading frame stem-loop | |
|---|---|
 Predicted secondary structure and sequence conservation of HCV_ARF_SL | |
| Identifiers | |
| Symbol | HCV_ARF_SL |
| Rfam | RF00620 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Viruses |
| SO | 0000233 |
| PDB structures | PDBe |
Hepatitis C alternative reading frame stem-loop is a conserved secondary structure motif identified in the RNA genome of the hepatitis C virus (HCV) which is proposed to have an important role in regulating translation and repression of the viral genome.
The core protein-coding region of the hepatitis C virus (HCV) genome contains a +1 alternative reading frame (ARF) and two proposed phylogenetically conserved RNA helix-forming stem loop structures (IV and VII).[1] The proteins translated from the ARF appear to be translated during the normal viral life cycle but are not essential to virus replication.[1] The two predicted stem loops shown here (SLV and SLVI) are proposed to be important for HCV translation and repression; these stem loops are located downstream of the internal ribosome entry site (IRES) but their functional role is unknown.[1]
See also
References
- ↑ 1.0 1.1 1.2 "Evidence for a functional RNA element in the hepatitis C virus coregene.". Proc Natl Acad Sci USA 104 (8): 2879–2884. 2007. doi:10.1073/pnas.0611267104. PMID 17299041. Bibcode: 2007PNAS..104.2879M.
External links
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