Biology:PAXBP1
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
GC-rich sequence DNA-binding factor homolog is a protein that in humans is encoded by the PAXBP1 gene.[1][2][3]
Similarity to a transcriptional repressor suggests that this gene's protein product is involved in the regulation of transcription. Alternative splicing of this gene results in three transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.[3]
References
- ↑ "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res 10 (10): 1546–60. Nov 2000. doi:10.1101/gr.140200. PMID 11042152.
- ↑ "From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map". Genomics 78 (1–2): 46–54. Nov 2001. doi:10.1006/geno.2001.6640. PMID 11707072.
- ↑ 3.0 3.1 "Entrez Gene: C21orf66 chromosome 21 open reading frame 66". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=94104.
External links
- Human PAXBP1 genome location and PAXBP1 gene details page in the UCSC Genome Browser.
Further reading
- "Criteria for gene identification and features of genome organization: analysis of 6.5 Mb of DNA sequence from human chromosome 21". Gene 247 (1–2): 215–32. 2000. doi:10.1016/S0378-1119(00)00089-5. PMID 10773462.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics 7: 155. 2006. doi:10.1186/1471-2164-7-155. PMID 16780588.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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