Biology:AACS (gene)
From HandWiki
 Generic protein structure example |
The acetoacetyl-CoA synthetase (AACS) gene encodes a protein of the same name, which converts acetoacetate to acetoacetyl-CoA, and plays a crucial role in ketone body utilization and fatty acid synthesis. The gene is found on human chromosome 12.
The AACS protein is a member of the acetyl-CoA synthetase family and is involved in cellular energy production, ketogenesis, and cholesterol synthesis.[1] It is expressed in a wide range of human tissues.[2]
Function
The protein's function is regulated transcriptionally by sterol regulatory element-binding protein (SREBP) and peroxisome proliferator-activated receptor gamma (PPARγ).[3]
References
- ↑ "Q86V21 · AACS_HUMAN". Uniprot. https://www.uniprot.org/uniprotkb/Q86V21/entry.
- ↑ "AACS acetoacetyl-CoA synthetase". NCBI Gene. https://www.ncbi.nlm.nih.gov/gene/65985.
- ↑ Aguiló, Francesca; Camarero, Nuria; Relat, Joana; Marrero, Pedro ; Haro, Diego (2010-03-29). "Transcriptional regulation of the human acetoacetyl-CoA synthetase gene by PPARγ". Biochemical Journal 427 (2): 255–264. doi:10.1042/bj20090851. ISSN 0264-6021. PMID 20102333. https://hal.science/hal-00479205/file/PEER_stage2_10.1042%252FBJ20090851.pdf.
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