Biology:DLGAP5
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Disks large-associated protein 5 (DAP-5) also known as discs large homolog 7 (DLG7) or hepatoma up-regulated protein (HURP) is a protein that in humans is encoded by the DLGAP5 gene.[1][2][3][4]
DLG7 is a kinetochore protein that stabilizes microtubules in vicinity of chromosomes. DLG7 controls spindle dynamics, promotes interkinetochore tension and efficient kinetochore capture.[5] DGL7 is a part of Ran-dependent complex.[6] Stabilization of DGL7 in cell occurs due to phosphorylation by Aurora A kinase.[7] Expression of DGL7 is found in cancer[8] and stem cells.[9]
References
- ↑ "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res 1 (1): 27–35. Dec 1995. doi:10.1093/dnares/1.1.27. PMID 7584026.
- ↑ "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res 1 (1): 47–56. Dec 1995. doi:10.1093/dnares/1.1.47. PMID 7584028.
- ↑ "Entrez Gene: DLG7 discs, large homolog 7 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9787.
- ↑ "Characterization of a novel human cell-cycle-regulated homologue of Drosophila dlg1". Genomics 77 (1–2): 5–7. September 2001. doi:10.1006/geno.2001.6570. PMID 11543626.
- ↑ Wilde A (June 2006). ""HURP on" we're off to the kinetochore!". J. Cell Biol. 173 (6): 829–31. doi:10.1083/jcb.200605150. PMID 16785318.
- ↑ "HURP is part of a Ran-dependent complex involved in spindle formation". Curr. Biol. 16 (8): 743–54. April 2006. doi:10.1016/j.cub.2006.03.056. PMID 16631581.
- ↑ "Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A". Mol. Cell. Biol. 25 (14): 5789–800. July 2005. doi:10.1128/MCB.25.14.5789-5800.2005. PMID 15987997.
- ↑ "Cell biology: Ran, mitosis and the cancer connection". Curr. Biol. 16 (12): R466–8. June 2006. doi:10.1016/j.cub.2006.05.032. PMID 16782004.
- ↑ "Gene expression analysis of hematopoietic progenitor cells identifies Dlg7 as a potential stem cell gene". Stem Cells 25 (6): 1498–506. June 2007. doi:10.1634/stemcells.2005-0479. PMID 17322106.
Further reading
- "Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins". DNA Res. 4 (1): 53–9. 1997. doi:10.1093/dnares/4.1.53. PMID 9179496.
- "Characterization of a novel human cell-cycle-regulated homologue of Drosophila dlg1". Genomics 77 (1–2): 5–7. 2001. doi:10.1006/geno.2001.6570. PMID 11543626.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma". Oncogene 22 (2): 298–307. 2003. doi:10.1038/sj.onc.1206129. PMID 12527899.
- "Regulation of the discs large tumor suppressor by a phosphorylation-dependent interaction with the beta-TrCP ubiquitin ligase receptor". J. Biol. Chem. 278 (43): 42477–86. 2004. doi:10.1074/jbc.M302799200. PMID 12902344.
- "Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells". J. Biol. Chem. 279 (11): 10157–66. 2004. doi:10.1074/jbc.M309843200. PMID 14699157.
- "Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line". Mol. Cell. Proteomics 3 (3): 279–86. 2004. doi:10.1074/mcp.D300003-MCP200. PMID 14729942.
- "Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region". J. Biol. Chem. 279 (31): 32592–602. 2004. doi:10.1074/jbc.M404950200. PMID 15145941.
- "Human Dlg protein binds to the envelope glycoproteins of human T-cell leukemia virus type 1 and regulates envelope mediated cell-cell fusion in T lymphocytes". J. Cell Sci. 117 (Pt 17): 3983–93. 2005. doi:10.1242/jcs.01266. PMID 15286176.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
- "KIAA0008 gene is associated with invasive phenotype of human hepatocellular carcinoma--a functional analysis". J. Cancer Res. Clin. Oncol. 130 (12): 719–27. 2005. doi:10.1007/s00432-004-0595-2. PMID 15340842.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A". Mol. Cell. Biol. 25 (14): 5789–800. 2005. doi:10.1128/MCB.25.14.5789-5800.2005. PMID 15987997.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. 2006. doi:10.1073/pnas.0507066103. PMID 16565220. Bibcode: 2006PNAS..103.5391N.
- "HURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture". J. Cell Biol. 173 (6): 879–91. 2006. doi:10.1083/jcb.200511132. PMID 16769820.
- "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. 2006. doi:10.1038/nbt1240. PMID 16964243.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
External links
- DLG7 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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