Biology:ANXA8L2

Short description: Protein

Generic protein structure example

Annexin A8-like protein 2 is a protein that in humans is encoded by the ANXA8L2 gene.

This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10.

External links

• Human ANXA8 genome location and ANXA8 gene details page in the UCSC Genome Browser.
• Human ANXA8L1 genome location and ANXA8L1 gene details page in the UCSC Genome Browser.

Further reading

• "Annexins: from structure to function.". Physiol. Rev. 82 (2): 331–71. 2002. doi:10.1152/physrev.00030.2001. PMID 11917092. 
• "Annexins: linking Ca2+ signaling to membrane dynamics.". Nat. Rev. Mol. Cell Biol. 6 (6): 449–61. 2005. doi:10.1038/nrm1661. PMID 15928709. 
• "Specific expression of the annexin VIII gene in acute promyelocytic leukemia.". Blood 79 (7): 1802–10. 1992. doi:10.1182/blood.V79.7.1802.1802. PMID 1313714. 
• "TaqI polymorphisms at the annexin VIII locus (ANX8).". Hum. Mol. Genet. 1 (7): 550. 1993. doi:10.1093/hmg/1.7.550. PMID 1364010. 
• "Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha.". Eur. J. Biochem. 185 (1): 63–71. 1989. doi:10.1111/j.1432-1033.1989.tb15082.x. PMID 2530088. 
• "Regulation of the expression of annexin VIII in acute promyelocytic leukemia.". Blood 84 (1): 279–86. 1994. doi:10.1182/blood.V84.1.279.279. PMID 8018923. 
• "Differential tissue expression of Annexin VIII in human.". FEBS Lett. 349 (1): 120–4. 1994. doi:10.1016/0014-5793(94)00559-1. PMID 8045287. 
• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. 2004. doi:10.1038/nature02462. PMID 15164054. Bibcode: 2004Natur.429..375D. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer.". Clin. Cancer Res. 11 (19 Pt 1): 6872–9. 2006. doi:10.1158/1078-0432.CCR-05-0547. PMID 16203777. 
• "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560. 
• "Annexin A8 displays unique phospholipid and F-actin binding properties.". FEBS Lett. 580 (10): 2430–4. 2006. doi:10.1016/j.febslet.2006.03.076. PMID 16638567.