Biology:IGHG1

IgG1 B12 heterotetramer, Human.

Generic protein structure example

Ig gamma-1 chain C region is a protein that in humans is encoded by the IGHG1 gene.

Further reading

• "[The rule of antibody structure. The primary structure of a monoclonal IgG1 immunoglobulin (myeloma protein Nie). III. The chymotryptic peptides of the H-chain, alignment of the tryptic peptides and discussion of the complete structure]". Hoppe-Seyler's Z. Physiol. Chem. 357 (11): 1571–604. 1977. doi:10.1515/bchm2.1976.357.2.1571. PMID 826475. 
• "[Rule of antibody structure. the primary structure of a monoclonal IgG1 immunoglobulin (myeloma protein Nie), I: Purification and characterization of the protein, the L- and H-chains, the cyanogenbromide cleavage products, and the disulfide bridges (author's transl)]". Hoppe-Seyler's Z. Physiol. Chem. 357 (11): 1515–40. 1977. doi:10.1515/bchm2.1976.357.2.1515. PMID 1002129. 
• "Crystal structure of a chimeric Fab' fragment of an antibody binding tumour cells.". J. Mol. Biol. 227 (1): 253–64. 1992. doi:10.1016/0022-2836(92)90695-G. PMID 1522589. 
• "The covalent structure of a human gamma G-immunoglobulin. X. Intrachain disulfide bonds.". Biochemistry 9 (16): 3188–96. 1971. doi:10.1021/bi00818a011. PMID 4923144. 
• "The covalent structure of a human gamma G-immunoglobulin. VII. Amino acid sequence of heavy-chain cyanogen bromide fragments H1-H4.". Biochemistry 9 (16): 3161–70. 1971. doi:10.1021/bi00818a008. PMID 5489771. 
• "The covalent structure of a human gamma G-immunoglobulin. 8. Amino acid sequence of heavy-chain cyanogen bromide fragments H5-H7.". Biochemistry 9 (16): 3171–81. 1971. doi:10.1021/bi00818a009. PMID 5530842. 
• "The nucleotide sequence of a human immunoglobulin C gamma1 gene.". Nucleic Acids Res. 10 (13): 4071–9. 1982. doi:10.1093/nar/10.13.4071. PMID 6287432. 
• "Structure of human immunoglobulin gamma genes: implications for evolution of a gene family.". Cell 29 (2): 671–9. 1982. doi:10.1016/0092-8674(82)90183-0. PMID 6811139. 
• "[Three-dimensional structure determination of antibodies. Primary structure of crystallized monoclonal immunoglobulin IgG1 KOL, I]". Hoppe-Seyler's Z. Physiol. Chem. 364 (6): 713–47. 1983. doi:10.1515/bchm2.1983.364.1.713. PMID 6884994. 
• Deisenhofer J (1981). "Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution.". Biochemistry 20 (9): 2361–70. doi:10.1021/bi00512a001. PMID 7236608. 
• "Variation in IgG1 heavy chain allotype does not contribute to differences in biological activity of two human anti-Rhesus (D) monoclonal antibodies.". Immunotechnology 4 (1): 37–47. 1998. doi:10.1016/S1380-2933(98)00005-0. PMID 9661813. 
• "Association of SWAP-70 with the B cell antigen receptor complex.". Proc. Natl. Acad. Sci. U.S.A. 97 (5): 2180–4. 2000. doi:10.1073/pnas.040374497. PMID 10681448. Bibcode: 2000PNAS...97.2180M. 
• "The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex.". Nature 406 (6793): 267–73. 2000. doi:10.1038/35018508. PMID 10917521. 
• "Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structures of abzyme 21D8.". J. Mol. Biol. 302 (5): 1213–25. 2000. doi:10.1006/jmbi.2000.4503. PMID 11183784. 
• "Human and murine immunoglobulin expression vector cassettes.". Mol. Immunol. 37 (14): 837–45. 2001. doi:10.1016/S0161-5890(00)00101-2. PMID 11257305. 
• "Structure of CD40 ligand in complex with the Fab fragment of a neutralizing humanized antibody.". Structure 9 (4): 321–9. 2001. doi:10.1016/S0969-2126(01)00590-1. PMID 11525169. 
• "Role of oligosaccharide residues of IgG1-Fc in Fc gamma RIIb binding.". J. Biol. Chem. 276 (49): 45539–47. 2002. doi:10.1074/jbc.M107478200. PMID 11567028. 
• "TNF-alpha, IL1-beta, and immunoglobulin (GM and KM) gene polymorphisms in sarcoidosis.". Hum. Immunol. 63 (6): 485–91. 2002. doi:10.1016/S0198-8859(02)00399-3. PMID 12039524. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.