Biology:Murphy Roths large
Murphy Roths large (MRL/MpJ) is a strain of laboratory mouse developed in 1999 at The Wistar Institute in Philadelphia, Pennsylvania.[1] Originally bred for autoimmune disease research, it was discovered to have remarkable tissue regeneration abilities.[2][3][4]
Research
The MRL/MpJ mouse strain was selectively bred by scientists to have an autoimmune genetic disorder (retained through inbreeding) to be used as a model for autoimmune disease research.[1] After making puncture wounds in their ears, these mice were observed to completely regenerate from these wounds without development of scar tissue.[1][2] In further research, this mouse strain has been observed to have the ability to also regenerate cardiac tissue, displays a resistance to muscle dystrophy, and is resistant to experiencing hyperglycemia from a diet high in fats.[5][6][7]
References
- ↑ 1.0 1.1 1.2 Clark, Lise Desquenne; Clark, Robert K.; Heber-Katz, Ellen (July 1998). "A New Murine Model for Mammalian Wound Repair and Regeneration". Clinical Immunology and Immunopathology 88 (1): 35–45. doi:10.1006/clin.1998.4519. ISSN 0090-1229. PMID 9683548.
- ↑ 2.0 2.1 Heber-Katz, E.; Leferovich, J. M.; Bedelbaeva, K.; Gourevitch, D. (2004). "Spallanzani's mouse: a model of restoration and regeneration". Current Topics in Microbiology and Immunology 280: 165–89. doi:10.1007/978-3-642-18846-6_5. ISBN 978-3-642-62321-9. PMID 14594211.
- ↑ Morelle, Rebecca (11 April 2006). "Mouse sheds light on regeneration". BBC News. http://news.bbc.co.uk/2/hi/science/nature/4888080.stm.
- ↑ Carswell, Lindsay (18 April 2006). "Self-healing Mice". ScienCentral News. http://www.sciencentral.com/articles/view.php3?article_id=218392774&cat=1_2.
- ↑ Heber-Katz, Ellen; Leferovich, John M.; Bedelbaeva, Khamilia (2001-12-01). "Spontaneous heart regeneration in adult MRL mice after cryoinjury". Gene Therapy and Regulation 1 (4): 399–407. doi:10.1163/156855801760107055. ISSN 1568-5586.
- ↑ Heydemann, Ahlke; Swaggart, Kayleigh; Kim, Gene H; Holley-Cuthrell, Jenan; Hadhazy, Michele; McNally, Elizabeth M (2012). "The superhealing MRL background improves muscular dystrophy". Skeletal Muscle 2 (1): 26. doi:10.1186/2044-5040-2-26. ISSN 2044-5040. PMID 23216833.
- ↑ Mull, Aaron J.; Berhanu, Tirsit K.; Roberts, Nathan W.; Heydemann, Ahlke (December 2014). "The Murphy Roths Large (MRL) mouse strain is naturally resistant to high fat diet-induced hyperglycemia". Metabolism 63 (12): 1577–1586. doi:10.1016/j.metabol.2014.09.007. ISSN 0026-0495. PMID 25308446.
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