Biology:ABCC13

Short description: Pseudogene in the species Homo sapiens

Generic protein structure example

Putative ATP-binding cassette transporter sub-family C member 13 is a protein that is not present in humans. In humans, ABCC13 is a pseudogene.

Function

This gene is a member of the superfamily of genes encoding ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This family member is part of the MRP subfamily, which is involved in multi-drug resistance, but the human locus is now thought to be a pseudogene incapable of encoding a functional ABC protein. Alternative splicing results in multiple transcript variants; however, not all variants have been fully described.

See also

• ATP-binding cassette transporter
• ABCC13+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

Further reading

• "Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates". Annual Review of Genomics and Human Genetics 6: 123–42. 2005. doi:10.1146/annurev.genom.6.080604.162122. PMID 16124856. 
• "Degeneration of an ATP-binding cassette transporter gene, ABCC13, in different mammalian lineages". Genomics 84 (1): 34–46. Jul 2004. doi:10.1016/j.ygeno.2004.02.010. PMID 15203202. 
• "An unappreciated role for RNA surveillance". Genome Biology 5 (2): R8. 2005. doi:10.1186/gb-2004-5-2-r8. PMID 14759258. 
• "Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms". Gene 312: 41–50. Jul 2003. doi:10.1016/S0378-1119(03)00530-4. PMID 12909339. 
• "ABCC13, an unusual truncated ABC transporter, is highly expressed in fetal human liver". Biochemical and Biophysical Research Communications 299 (3): 410–7. Dec 2002. doi:10.1016/S0006-291X(02)02658-X. PMID 12445816. 
• "Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis". Genomics 79 (6): 833–43. Jun 2002. doi:10.1006/geno.2002.6782. PMID 12036298. 
• "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Human Molecular Genetics 5 (10): 1649–55. Oct 1996. doi:10.1093/hmg/5.10.1649. PMID 8894702. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.