Biology:Grancalcin
 Generic protein structure example |
Grancalcin is a protein that in humans is encoded by the GCA gene.[1][2][3][4]
This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.[4]
Interactions
GCA (gene) has been shown to interact with SRI.[3]
References
- ↑ "Molecular cloning and characterization of grancalcin, a novel EF-hand calcium-binding protein abundant in neutrophils and monocytes". J Biol Chem 267 (5): 2928–33. Mar 1992. doi:10.1016/S0021-9258(19)50675-5. PMID 1737748.
- ↑ "Isolation and characterization of grancalcin, a novel 28 kDa EF-hand calcium-binding protein from human neutrophils". Biochem J. 286 ( Pt 2) (2): 549–54. Oct 1992. doi:10.1042/bj2860549. PMID 1530588.
- ↑ 3.0 3.1 "The PEF family proteins sorcin and grancalcin interact in vivo and in vitro". FEBS Lett 545 (2–3): 151–4. Jun 2003. doi:10.1016/S0014-5793(03)00518-0. PMID 12804766.
- ↑ 4.0 4.1 "Entrez Gene: GCA grancalcin, EF-hand calcium binding protein". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25801.
Further reading
- "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. 2006. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. 2005. doi:10.1038/nature03466. PMID 15815621. Bibcode: 2005Natur.434..724H.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Structure of Ca(2+)-loaded human grancalcin.". Acta Crystallogr. D 57 (Pt 12): 1843–9. 2002. doi:10.1107/S0907444901016511. PMID 11717497.
- "Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner.". J. Biol. Chem. 276 (21): 17762–9. 2001. doi:10.1074/jbc.M100965200. PMID 11279160.
- "Crystal structure of human grancalcin, a member of the penta-EF-hand protein family.". J. Mol. Biol. 300 (5): 1271–81. 2000. doi:10.1006/jmbi.2000.3925. PMID 10903868.
- "A growing family of the Ca2+-binding proteins with five EF-hand motifs.". Biochem. J.. 328 ( Pt 2) (Pt 2): 718–20. 1998. PMID 9441591.
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