Biology:SKIL
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Ski-like protein is a protein that in humans is encoded by the SKIL gene.[1][2]
Interactions
SKIL interacts with SKI protein,[3] Mothers against decapentaplegic homolog 3[4][5] and Mothers against decapentaplegic homolog 2.[4][5]
Protein Family
SKIL belongs to the Ski/Sno/Dac family, shared by SKI protein, Dachshund, and SKIDA1.[6] Members of the Ski/Sno/Dac family share a domain that is roughly 100 amino acids long.
References
- ↑ Nomura N; Sasamoto S; Ishii S; Date T; Matsui M; Ishizaki R (September 1989). "Isolation of human cDNA clones of ski and the ski-related gene, sno". Nucleic Acids Res 17 (14): 5489–500. doi:10.1093/nar/17.14.5489. PMID 2762147.
- ↑ "Entrez Gene: SKIL SKI-like oncogene". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6498.
- ↑ Cohen, S B; Zheng G; Heyman H C; Stavnezer E (February 1999). "Heterodimers of the SnoN and Ski oncoproteins form preferentially over homodimers and are more potent transforming agents". Nucleic Acids Res. (ENGLAND) 27 (4): 1006–14. doi:10.1093/nar/27.4.1006. ISSN 0305-1048. PMID 9927733.
- ↑ 4.0 4.1 Stroschein, S L; Bonni S; Wrana J L; Luo K (November 2001). "Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN". Genes Dev. (United States) 15 (21): 2822–36. doi:10.1101/gad.912901. ISSN 0890-9369. PMID 11691834.
- ↑ 5.0 5.1 Stroschein, S L; Wang W; Zhou S; Zhou Q; Luo K (October 1999). "Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein". Science (UNITED STATES) 286 (5440): 771–4. doi:10.1126/science.286.5440.771. ISSN 0036-8075. PMID 10531062. https://zenodo.org/record/1231169.
- ↑ "Conserved Protein Domain Family Ski_Sno". https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=334932.
Further reading
- Pearson-White S (1993). "SnoI, a novel alternatively spliced isoform of the ski protooncogene homolog, sno". Nucleic Acids Res. 21 (19): 4632–8. doi:10.1093/nar/21.19.4632. PMID 8233802.
- Pearson-White S; Crittenden R (1997). "Proto-oncogene Sno expression, alternative isoforms and immediate early serum response". Nucleic Acids Res. 25 (14): 2930–7. doi:10.1093/nar/25.14.2930. PMID 9207045.
- Cohen SB; Zheng G; Heyman HC; Stavnezer E (1999). "Heterodimers of the SnoN and Ski oncoproteins form preferentially over homodimers and are more potent transforming agents". Nucleic Acids Res. 27 (4): 1006–14. doi:10.1093/nar/27.4.1006. PMID 9927733.
- "Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein". Science 286 (5440): 771–4. 1999. doi:10.1126/science.286.5440.771. PMID 10531062. https://zenodo.org/record/1231169.
- "TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation". Nat. Cell Biol. 3 (6): 587–95. 2001. doi:10.1038/35078562. PMID 11389444.
- "SNO is a probable target for gene amplification at 3q26 in squamous-cell carcinomas of the esophagus". Biochem. Biophys. Res. Commun. 286 (3): 559–65. 2001. doi:10.1006/bbrc.2001.5428. PMID 11511096.
- Stroschein SL; Bonni S; Wrana JL; Luo K (2001). "Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN". Genes Dev. 15 (21): 2822–36. doi:10.1101/gad.912901. PMID 11691834.
- "Two short segments of Smad3 are important for specific interaction of Smad3 with c-Ski and SnoN". J. Biol. Chem. 278 (1): 531–6. 2003. doi:10.1074/jbc.C200596200. PMID 12426322.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Tomsig JL; Snyder SL; Creutz CE (2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif". J. Biol. Chem. 278 (12): 10048–54. doi:10.1074/jbc.M212632200. PMID 12522145.
- "The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteins". J. Biol. Chem. 278 (33): 30540–7. 2003. doi:10.1074/jbc.M304016200. PMID 12764135. https://digital.library.unt.edu/ark:/67531/metadc733634/m2/1/high_res_d/816560.pdf.
- "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. 2004. doi:10.1101/gr.2334104. PMID 15231748.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- Sarker KP; Wilson SM; Bonni S (2005). "SnoN is a cell type-specific mediator of transforming growth factor-beta responses". J. Biol. Chem. 280 (13): 13037–46. doi:10.1074/jbc.M409367200. PMID 15677458.
- "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–5. 2005. doi:10.1126/science.1105776. PMID 15761153. Bibcode: 2005Sci...307.1621B.
- "Characterization of Sno expression in malignant melanoma". Int. J. Oncol. 26 (5): 1411–7. 2005. doi:10.3892/ijo.26.5.1411. PMID 15809735.
- "Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-β signaling by sequestration of the Smad proteins". Proc. Natl. Acad. Sci. U.S.A. 102 (35): 12437–42. 2005. doi:10.1073/pnas.0504107102. PMID 16109768. Bibcode: 2005PNAS..10212437K.
- Zhu Q; Pearson-White S; Luo K (2006). "Requirement for the SnoN Oncoprotein in Transforming Growth Factor β-Induced Oncogenic Transformation of Fibroblast Cells". Mol. Cell. Biol. 25 (24): 10731–44. doi:10.1128/MCB.25.24.10731-10744.2005. PMID 16314499.
- "SnoN co-repressor binds and represses smad7 gene promoter". Biochem. Biophys. Res. Commun. 341 (3): 889–94. 2006. doi:10.1016/j.bbrc.2006.01.041. PMID 16442497.
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