Biology:HM13
 Generic protein structure example |
Minor histocompatibility antigen H13 is a protein that in humans is encoded by the HM13 gene.[1][2][3]
Function
The minor histocompatibility antigen 13 is a nonamer peptide that originates from a protein encoded by the H13 gene.[4][5] The peptide is generated by the cytosol by the proteasome, enters the endoplasmic reticulum (ER) lumen by the transporter associated with antigen processing (TAP) and is presented on the cell surface on H2-Db major histocompatibility antigen I (MHC I) molecules. The alloreactivity, which leads to transplant rejection in mice, is conferred by Val/Ile polymorphism in the ‘SSV(V/I)GVWYL’ peptide.[6] The orthologue gene in humans is called HM13. If a related polymorphism exists, and if the HM13 serves as a Minor histocompatibility antigen, however, remains to be addressed.
The protein encoded by the M13/HM13 gene is the signal peptide peptidase (SPP), an ER-resident intramembrane protease.[1] SPP localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene.[3]
References
- ↑ 1.0 1.1 "Identification of signal peptide peptidase, a presenilin-type aspartic protease". Science 296 (5576): 2215–8. Jun 2002. doi:10.1126/science.1070925. PMID 12077416. Bibcode: 2002Sci...296.2215W.
- ↑ "Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor". J Biol Chem 279 (15): 15153–60. Apr 2004. doi:10.1074/jbc.M309305200. PMID 14704149.
- ↑ 3.0 3.1 "Entrez Gene: HM13 histocompatibility (minor) 13". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81502.
- ↑ "Entrez Gene: H13 histocompatibility (minor) 13". https://www.ncbi.nlm.nih.gov/gene/14950.
- ↑ "Histocompatibility genes of mice. VII. H-13, a new histocompatibility locus in the fifth linkage group". Transplantation 5 (3): 492–503. Jun 1967. doi:10.1097/00007890-196705000-00011. PMID 5340356.
- ↑ "Minors held by majors: the H13 minor histocompatibility locus defined as a peptide/MHC class I complex". Immunity 7 (4): 461–72. Oct 1997. doi:10.1016/S1074-7613(00)80368-4. PMID 9354467.
Further reading
- "Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E epitopes". J. Immunol. 167 (11): 6441–6. 2002. doi:10.4049/jimmunol.167.11.6441. PMID 11714810.
- "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. 2002. doi:10.1038/414865a. PMID 11780052. Bibcode: 2001Natur.414..865D.
- "Novel class of polytopic proteins with domains associated with putative protease activity". Biochemistry Mosc. 67 (7): 826–35. 2002. doi:10.1023/A:1016365227942. PMID 12139484.
- "Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets". EMBO J. 21 (15): 3980–8. 2002. doi:10.1093/emboj/cdf414. PMID 12145199.
- "Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis". Mol. Cell 10 (4): 735–44. 2002. doi:10.1016/S1097-2765(02)00655-X. PMID 12419218.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Expression of the presenilin-like signal peptide peptidase (SPP) in mouse adult brain and during development". Gene Expr. Patterns 3 (5): 685–91. 2004. doi:10.1016/S1567-133X(03)00094-2. PMID 12972007.
- "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics 83 (1): 153–67. 2004. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Impas 1 possesses endoproteolytic activity against multipass membrane protein substrate cleaving the presenilin 1 holoprotein". FEBS Lett. 557 (1–3): 185–92. 2004. doi:10.1016/S0014-5793(03)01489-3. PMID 14741365.
- "Correlation between conformation and antibody binding: NMR structure of cross-reactive peptides from T. cruzi, human and L. braziliensis". FEBS Lett. 560 (1–3): 134–40. 2004. doi:10.1016/S0014-5793(04)00088-2. PMID 14988012.
- "Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins". J. Biol. Chem. 279 (49): 50790–8. 2005. doi:10.1074/jbc.M407898200. PMID 15385547.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. 2007. doi:10.1093/dnares/12.2.117. PMID 16303743.
- "Cell-surface expression of a new splice variant of the mouse signal peptide peptidase". Biochim. Biophys. Acta 1759 (3–4): 159–65. 2006. doi:10.1016/j.bbaexp.2006.02.007. PMID 16730383.
- "Signal peptide peptidase is required for dislocation from the endoplasmic reticulum". Nature 441 (7095): 894–7. 2006. doi:10.1038/nature04830. PMID 16738546. Bibcode: 2006Natur.441..894L.
- "Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs". Biochemistry 45 (28): 8649–56. 2006. doi:10.1021/bi060597g. PMID 16834339.
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