Biology:XAGE1D

Short description: Protein-coding gene in humans

Generic protein structure example

G antigen family D member 2 is a protein that in humans is encoded by the XAGE1D gene.

This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene generates 3 transcript variants, and one of which includes 2 transcripts generated from alternate transcription initiation sites.

Further reading

• "Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database". Cancer Research 59 (7): 1445–8. April 1999. PMID 10197611. 
• "XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma". Cancer Research 60 (17): 4752–5. September 2000. PMID 10987281. 
• "Characterization of XAGE-1b, a short major transcript of cancer/testis-associated gene XAGE-1, induced in melanoma metastasis". International Journal of Cancer 97 (2): 195–204. January 2002. doi:10.1002/ijc.1584. PMID 11774264. 
• "The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma". International Journal of Cancer 99 (3): 361–9. May 2002. doi:10.1002/ijc.10371. PMID 11992404. 
• "Characterization of overlapping XAGE-1 transcripts encoding a cancer testis antigen expressed in lung, breast, and other types of cancers". Molecular Cancer Therapeutics 1 (7): 441–50. May 2002. PMID 12479262. 
• "Activation of human cancer/testis antigen gene, XAGE-1, in tumor cells is correlated with CpG island hypomethylation". International Journal of Cancer 116 (2): 200–6. August 2005. doi:10.1002/ijc.21007. PMID 15800911. 
• "XAGE-1 expression in non-small cell lung cancer and antibody response in patients". Clinical Cancer Research 11 (15): 5496–503. August 2005. doi:10.1158/1078-0432.CCR-05-0216. PMID 16061866. 
• "Identification of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors". Cancer Immunity 7: 5. March 2007. PMID 17335148.