Biology:Scianna antigen system
From HandWiki
The Scianna blood antigen system consists of seven antigens.[1][2] These include two high frequency antigens Sc1 and Sc3, and two low frequency antigens Sc2 and Sc4.[1] The very rare null phenotype is characterised by the absence of Sc1, Sc2 and Sc3.[1]
The antigens are caused by changes in the erythroid membrane associated protein (ERMAP).[3][4]
History
This blood group system was discovered in 1962 when a high frequency antigen was detected in a young woman (Ms. Scianna) who had experienced several late pregnancy losses due to haemolytic disease of the fetus.[3]
References
- ↑ 1.0 1.1 1.2 "Scianna Blood Group System" (in en), Human Blood Groups, Wiley-Blackwell, 2013-01-28, pp. 371–375, doi:10.1002/9781118493595.ch13, ISBN 9781118493595
- ↑ "Table of blood group systems". ISBT. https://www.isbtweb.org/fileadmin/user_upload/Red_Cell_Terminology_and_Immunogenetics/Table_of_blood_group_systems_v6_180621.pdf.
- ↑ 3.0 3.1 Brunker, Patricia; Flegel, Willy (2011). "Scianna: the lucky 13th blood group system". Immunohematology 27 (2): 41–57. doi:10.21307/immunohematology-2019-173. PMID 22356519.
- ↑ Wagner, F. F.; Poole, Joyce; Flegel, Willy (2003-01-15). "Scianna antigens including Rd are expressed by ERMAP". Blood 101 (2): 752–757. doi:10.1182/blood-2002-07-2064. PMID 12393480.
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