Biology:MAGEB2
 Generic protein structure example |
Melanoma-associated antigen B2 is a protein that in humans is encoded by the MAGEB2 gene.[1][2]
This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21.[2]
References
- ↑ "Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins". Genomics 46 (3): 397–408. Mar 1998. doi:10.1006/geno.1997.5052. PMID 9441743.
- ↑ 2.0 2.1 "Entrez Gene: MAGEB2 melanoma antigen family B, 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4113.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "A family of rapidly evolving genes from the sex reversal critical region in Xp21.". Mamm. Genome 6 (9): 571–80. 1996. doi:10.1007/BF00352360. PMID 8535061.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "MAGE Xp-2: a member of the MAGE gene family isolated from an expression library using systemic lupus erythematosus sera.". Mol. Genet. Metab. 63 (1): 3–13. 1998. doi:10.1006/mgme.1997.2639. PMID 9538511.
- "Identification, expression, and nuclear location of murine Mage-b2 protein, a tumor-associated antigen.". Mol. Cells 10 (6): 647–53. 2001. doi:10.1007/s10059-000-0647-7. PMID 11211869.
- "Hypertonicity induction of melanoma antigen, a tumor-associated antigen.". Mol. Cells 13 (2): 288–95. 2003. PMID 12018852.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. 2005. doi:10.1038/nature03440. PMID 15772651. Bibcode: 2005Natur.434..325R.
- "Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes.". Carcinogenesis 28 (3): 560–71. 2007. doi:10.1093/carcin/bgl167. PMID 17012225.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
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