Biology:TRHDE

Short description: Protein-coding gene in the species Homo sapiens

Thyrotropin releasing hormone degrading enzyme is a protein, specifically a pyroglutamyl-peptidase II enzyme, that in humans is encoded by the TRHDE gene.

Function

This gene encodes a member of the peptidase M1 family. The encoded protein is an extracellular peptidase that specifically cleaves and inactivates the neuropeptide thyrotropin-releasing hormone.

Further reading

• "Vimentin is a novel AKT1 target mediating motility and invasion". Oncogene 30 (4): 457–70. January 2011. doi:10.1038/onc.2010.421. PMID 20856200. 
• "PAP I interacts with itself, PAP II, PAP III, and lithostathine/regIalpha". Molecular Cell Biology Research Communications 2 (3): 150–4. 1999. doi:10.1006/mcbr.1999.0166. PMID 10662590. 
• "Chemerin, a novel adipokine in the regulation of angiogenesis". The Journal of Clinical Endocrinology and Metabolism 95 (5): 2476–85. May 2010. doi:10.1210/jc.2010-0042. PMID 20237162. 
• "Genome-wide association study of rheumatoid arthritis in Koreans: population-specific loci as well as overlap with European susceptibility loci". Arthritis and Rheumatism 63 (4): 884–93. April 2011. doi:10.1002/art.30235. PMID 21452313. 
• "Human TRH-degrading ectoenzyme cDNA cloning, functional expression, genomic structure and chromosomal assignment". European Journal of Biochemistry 265 (1): 415–22. October 1999. doi:10.1046/j.1432-1327.1999.00753.x. PMID 10491199. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.