Biology:NELL1
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Protein kinase C-binding protein NELL1 also known as NEL-like protein 1 (NELL1) or Nel-related protein 1 (NRP1) is a protein that in humans is encoded by the NELL1 gene.[1][2][3]
Function
This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF) -like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. An alternative splice variant has been described but its full-length sequence has not been determined.[2]
Recent study by UCLA researchers shows that administering the protein NELL-1 intravenously stimulates significant bone formation through the regenerative ability of stem cells.[3]
References
- ↑ "Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats". Genomics 38 (3): 273–6. Mar 1997. doi:10.1006/geno.1996.0628. PMID 8975702.
- ↑ 2.0 2.1 "Entrez Gene: NELL1 NEL-like 1 (chicken)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4745.
- ↑ 3.0 3.1 "Study reveals bone-building protein's impact on bone stem cells". http://medicalxpress.com/news/2015-06-reveals-bone-building-protein-impact-bone.html.
Further reading
- "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III 318 (2): 263–72. 1995. PMID 7757816.
- "Human NELL-1 expressed in unilateral coronal synostosis.". J. Bone Miner. Res. 14 (1): 80–9. 1999. doi:10.1359/jbmr.1999.14.1.80. PMID 9893069.
- "The neuronal EGF-related genes NELL1 and NELL2 are expressed in hemopoietic cells and developmentally regulated in the B lineage.". Gene 231 (1–2): 121–6. 1999. doi:10.1016/S0378-1119(99)00093-1. PMID 10231576.
- "Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2". Biochem. Biophys. Res. Commun. 265 (1): 79–86. 1999. doi:10.1006/bbrc.1999.1638. PMID 10548494.
- "Brain specific human genes, NELL1 and NELL2, are predominantly expressed in neuroblastoma and other embryonal neuroepithelial tumors". Neurol. Med. Chir. (Tokyo) 41 (12): 582–8; discussion 589. 2002. doi:10.2176/nmc.41.582. PMID 11803583.
- "Craniosynostosis in transgenic mice overexpressing Nell-1". J. Clin. Invest. 110 (6): 861–70. 2002. doi:10.1172/JCI15375. PMID 12235118.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Identification of NAD+-dependent isocitrate dehydrogenase 3 gamma-like (IDH3GL) gene and its genetic polymorphisms". Gene 323: 141–8. 2004. doi:10.1016/j.gene.2003.09.014. PMID 14659887.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD)". Am. J. Hum. Genet. 74 (6): 1255–61. 2004. doi:10.1086/421527. PMID 15124103.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. 2006. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- "Craniosynostosis-associated gene nell-1 is regulated by runx2". J. Bone Miner. Res. 22 (1): 7–18. 2007. doi:10.1359/jbmr.061012. PMID 17042739.
- "Hypermethylation of the nel-like 1 gene is a common and early event and is associated with poor prognosis in early-stage esophageal adenocarcinoma". Oncogene 26 (43): 6332–40. 2007. doi:10.1038/sj.onc.1210461. PMID 17452981.
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